AGING & VISUAL-SPECIFICITY OF EXPLICIT & IMPLICIT MEMORY

老化

• 批准号: 6464018
• 负责人: HALINE E SCHENDAN
• 金额: $ 4.62万
• 依托单位: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-11-01 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6464018
• 关键词: Alzheimer's disease; Parkinson's disease; age difference; behavioral /social science research tag; clinical research; evoked potentials; functional magnetic resonance imaging; human old age (65+); human subject; magnetoencephalography; memory; memory disorders; visual perception; young adult human (21-34)

A key feature of normal aging is that memory becomes less rich in perceptual and conceptual details. This property has been proposed to primarily reflect a tendency of elderly to retrieve events in a less specific and so more generic manner than young people and to a lesser extent encoding that is less perceptually and conceptually distinct. Proposed research investigates changes with age in neural systems supporting memory for perceptual details. To do so, the visual-specificity of brain areas supporting explicit and implicit memory for particular perceptual properties (view size) of objects and faces are assessed using 2 complementary techniques. 1. Neuropsychological studies use Parkinson's disease as a model for frontal-basal ganglionic dysfunction and mild Alzheimer's dementia as a model for MTL and posterior extrastriate dysfunction to assess the contributions of these brain systems to changes in normal aging age-related disorders. 2. Combined event-related functional magnetic resonance imaging (fMRI) and simultaneous magnetoencephalogram (MEG) and event-related potential (ERP) recordings in the same young and old normal people define differences in the functional dynamics of young and aged brains that may impair perceptual memory. Experiments use implicit memory tests, and explicit memory is assessed using recognition (not recall) tests to reveal the extent to which implicit and explicit perceptual representations are encoded and potentially available for retrieval using frontal lobe strategic search processes that are impaired with age. Findings will also contribute to the functional characterization of these brain systems, and by defining brain areas underlying age-related memory disturbances, the work addresses a clinical goal of specifying which regions should be targeted by treatments.

正常衰老的一个关键特征是记忆变得不那么丰富的感知和概念细节。已经提出该属性主要反映老年人以比年轻人更不具体和更通用的方式检索事件的趋势，并且在较小程度上编码在感知和概念上不那么明显。拟议的研究调查了支持感知细节记忆的神经系统随年龄的变化。要做到这一点，视觉特异性的大脑区域支持外显和内隐记忆的特定感知属性（视图大小）的对象和面孔进行评估，使用2个互补的技术。1.神经心理学研究使用帕金森病作为额基底神经节功能障碍的模型和轻度阿尔茨海默氏痴呆症作为MTL和后纹外功能障碍的模型，以评估这些脑系统对正常衰老年龄相关疾病变化的贡献。2.结合事件相关功能磁共振成像（fMRI）和同步脑磁图（MEG）和事件相关电位（ERP）记录在相同的年轻和老年正常人定义的差异，在年轻和老年人的大脑功能动力学，可能会损害知觉记忆。实验使用内隐记忆测试，外显记忆使用识别（不回忆）测试进行评估，以揭示内隐和外显感知表征编码的程度，并可能用于检索使用额叶策略搜索过程，随着年龄的增长而受损。研究结果还将有助于这些大脑系统的功能表征，并通过定义与年龄相关的记忆障碍相关的大脑区域，这项工作解决了指定哪些区域应该被治疗的临床目标。