Improved 3D MRI with cylindrical trajectories

改进的 3D MRI 圆柱轨迹

• 批准号: 6484428
• 负责人: Kai Ruppert
• 金额: $ 9.71万
• 依托单位: ADVANCED MRI TECHNOLOGY, LLC
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-04-22 至 2003-01-21
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6484428
• 关键词: bioimaging /biomedical imaging; biomedical equipment development; brain imaging /visualization /scanning; computer program /software; gas; image enhancement; image processing; magnetic resonance imaging; phantom model; whole body imaging /scanning

DESCRIPTION (provided by applicant): We are proposing the development of a family of 3D single-slab MRI pulse sequences based on interleaved cylindrical k-space trajectories. Spin-echo-train and gradient-echo versions will be implemented on a state-of-the-art commercially available whole-body MR scanner equipped with high-performance gradients. This trajectory type features a rare combination of beneficial characteristics: high sampling efficiency, excellent off-resonance behavior, low diffusion and flow sensitivity as well as drastically reduced RF radiation exposure of the examined subject. Various optimized sequence variants will be incorporated into 3D product sequences that will benefit such diverse research areas as high-speed, high-resolution brain MRJ, contrast-enhanced MRA, high-field MRI and hyperpolarized-gas MRI, The success of each developmental step will be ensured by a stringent image quality control that ensures that the signal-to-noise and the overall image artifact load for a given set of sequence parameters is equal to or better than the competing conventional MRI pulse sequences based on rectilinear or spiral trajectories. During the commercialization phase the developed set of pulse sequences will be ported for suitable hardware and software platforms of all major MR hardware manufacturers.

描述（由申请人提供）：我们正在提议开发一种 基于交错柱面的3D单层MRI脉冲序列族 k空间轨迹自旋回波序列和梯度回波版本将 在最先进的市售全身MR扫描仪上实现 配备高性能梯度。这种弹道类型具有罕见的 组合的有益特点：采样效率高，优良的 非共振行为，低扩散和流动敏感性，以及 大大减少了受检者的RF辐射暴露。各种 优化的序列变体将被并入3D产物序列中， 将有利于高速、高分辨率大脑等不同研究领域 MRJ、对比增强MRA、高场MRI和超极化气体MRI， 严格的图像质量将确保每个开发步骤的成功 确保信噪比和整体图像伪影 给定序列参数集的负载等于或优于 基于直线或螺旋的竞争常规MRI脉冲序列 轨迹在商业化阶段， 序列将被移植到合适的硬件和软件平台的所有 主要的MR硬件制造商。