Xenon Polarization Transfer Contrast MRI of Lung

肺氙偏振传输对比 MRI

• 批准号: 6444112
• 负责人: Kai Ruppert
• 金额: $ 9.88万
• 依托单位: ADVANCED MRI TECHNOLOGY, LLC
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-27 至 2004-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6444112
• 关键词: bioimaging /biomedical imaging; contrast media; diagnosis design /evaluation; lung disorder; lung imaging /visualization /scanning; magnetic resonance imaging; optical polarization; radiowave radiation; respiratory disorder diagnosis; technology /technique development; xenon

DESCRIPTION (provided by applicant): We are proposing the development of an MRI pulse sequence package based on the recently invented Xenon Polarization transfer Contrast (XTC) MRI. Upon inhalation of a batch of hyperpolarized 129Xe, the lipophilic xenon dissolves almost instantaneously in the lung tissue and the blood. Although only a small fraction of the gas (ca. 2 percent) is dissolved at any point in time it is nevertheless standing in fast exchange with the much larger gas pool in the air spaces of the lung. Selective destruction of the magnetization of the dissolved 129Xe with the application of a series of frequency selective radio frequency pulses that leave The gas phase magnetization undisturbed makes it possible to encode certain physiological parameters of the parenchyma as intensity variations in the gas phase images The proposed precise characterization of the exchange parameters and their variability in healthy subjects as well as the maximization of the available dynamic range are the key steps for a successful MRI pulse sequence implementation. These results will permit the development of a novel, noninvasive in-viva diagnostic tool that can be sensitized for a range of pathological changes in the lung morphology or function.

描述（由申请人提供）：我们建议开发MRI 基于最近发明的氙极化的脉冲序列包 转移对比度（XTC）MRI。在吸入一批超极化的 亲脂性氙在肺组织中几乎瞬间溶解 还有血虽然只有一小部分的气体（约。（2%） 在任何时间点解散，它仍然站在快速交换， 肺的气腔中有更大的气池。选择性 溶解的129的磁化的破坏与应用 一系列频率选择性射频脉冲， 不受干扰的磁化使编码某些生理 作为气相图像中强度变化的实质参数 提出的交换参数的精确表征及其 健康受试者的变异性以及可用药物的最大化 动态范围是成功MRI脉冲序列的关键步骤 实施.这些结果将允许开发一种新的， 非侵入性体内诊断工具，可对一系列 肺形态或功能的病理变化。