Defining the mechano-chemical signals controlling cancer cell invasion

定义控制癌细胞侵袭的机械化学信号

• 批准号: 2088115
• 金额: --
• 依托单位: King's College London
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2018
• 资助国家: 英国
• 起止时间: 2018 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2088115
• 关键词: Defining; mechano; chemical; signals; controlling

Cancer metastasis initiates through invasion of subsets of cells away from the primary tumour into the surrounding stroma and towards the blood stream. The organisation of tumour microenvironment, including the mechanical properties of the matrix, is known to influence the mode and dynamics of invasion but the mechanisms governing this remain poorly defined. This project will combine advanced microscopy, biophysics and computational analysis to define the precise local mechano-chemical signalling cues that drive tumour cell invasion into 3-dimensional matrices. Data arising from the study will provide novel insight into the signalling specification of invasive cells and potentially reveal new ways to prevent metastasis.

癌症转移通过远离原发性肿瘤的细胞亚群侵入周围基质并朝向血流而开始。已知肿瘤微环境的组织，包括基质的机械性质，会影响侵袭的模式和动力学，但对此的机制仍不清楚。该项目将结合联合收割机先进的显微镜，生物物理学和计算分析，以确定精确的局部机械化学信号线索，驱动肿瘤细胞侵入三维矩阵。该研究产生的数据将为侵入性细胞的信号转导提供新的见解，并可能揭示预防转移的新方法。