DEPRESSION AND TRIAL OF VARICELLA VACCINE IN THE ELDERLY

描述(改编自调查员摘要)：令人信服的证据 研究表明，作为抑郁症的动物模型，不可避免的压力会增加 对病毒性疾病的易感性，如单纯疱疹、流感和 柯萨奇病毒通过免疫功能改变而感染。然而， 将这些基本观察转化为临床环境是有限的， 以及严重抑郁症的免疫学后果及其可能的 与传染病的临床相关性仍不清楚。此外， 对抑郁症受试者的免疫学研究尚未评估疾病特异性 免疫措施也未检测与以下相关的体内免疫反应 结果。这项研究假设患有严重抑郁症的老年人 水痘-带状疱疹病毒(VZV)感染重新激活的风险增加。 因为许多证据表明，细胞免疫在 在限制带状疱疹及其并发症发生方面的作用， 严重抑郁对VZV特异性细胞免疫的影响将是 检查过了。使用特定疾病的方法，这项研究还将评估 抑郁症患者对VZV疫苗的整体体内免疫应答的完整性 受试者与对照组比较。本项目的具体目标是：1) 确定重度抑郁障碍是否与VZV下降有关 60岁及以上成年人的特异性免疫；以及2)评估 严重的抑郁障碍会减弱抑郁症的程度或持续时间 疫苗刺激的老年人患HZ和HZ的风险增加 检测已知与VZV相关的VZV特异性免疫指标 HZ及其并发症的发生、严重程度及研究进展 我们的模型是另一个主要优势，它将产生关于 抑郁症患者的免疫系统如何对一种抗原做出反应 传染性病原体。

DESCRIPTION (adapted from investigator's abstract): Compelling evidence has shown that inescapable stress, a putative animal model of depression, increases susceptibility to viral diseases such as herpes simplex, influenza, and coxsackie virus infections via alterations in immune function. However, translation of these basic observations into the clinical setting is limited, and the immunological consequences of major depression and their possible clinical relevance to infectious diseases remain unknown. Moreover, immunological studies of depressed subjects have not evaluated disease specific immune measures nor assayed in vivo immune responses that correlate with outcome. This study hypothesizes that older adults with major depression are at increased risk for reactivation of varicella-zoster virus (VZV) infection. Because much evidence indicates that cell mediated immunity plays a critical role in limiting the occurrence of herpes zoster (HZ) and its complications, the effect of major depression on VZV-specific cellular immunity will be examined. Using a disease specific approach, this study will also evaluate the integrity of an integrated, in vivo immune response to VZV vaccine in depressed subjects as compared to controls. The specific aims of this project are to: 1) determine whether major depressive disorder is associated with declines in VZV specific immunity in adults 60 years of age and older; and 2) evaluate whether major depressive disorder attenuates the magnitude or duration of vaccine-stimulated virtue of their older age are at increased risk for HZ and assaying VZV specific immunological measures that are known to correlate with the occurrence and severity of HZ and its complications, this study advances our model, another major strength, will yield substantial new information about how the immune system of depressed subjects responds to an antigen of an infectious pathogen.