Gordon Conference: Cancer Genetics and Epigenetics 2003

描述（由申请人提供）：本申请是为2003年1月中旬在加州文图拉港镇喜来登举行的戈登研究会议（GRC）主持的“癌症遗传学和表观遗传学”会议提供部分资金。在这一领域特别激动人心的时刻，这将是关于这一主题的第四届两年一度的GRC会议。本次会议涉及的所有领域的工作都在以越来越快的速度取得进展。这使得研究人员之间的交流变得更加重要。在本次会议上，研究癌症研究和相关基本遗传/表观遗传机制的与会者（最多130人）将就当前主题的演讲进行辩论，评论海报演讲，并开展非正式讨论。会议将有9个演讲环节和每日海报环节。将从提交的摘要中选出海报演示文稿以及9名以上的演讲者。因此，本次会议将为年轻的研究者和最新的数据提供一个很好的展示机会，同时也将汇聚国际知名的资深科学家。按照本系列会议的传统，将强调正式讨论，每次发言后留出15-20分钟的辩论时间。本次会议将为研究癌症分子生物学和研究基因调控基本机制的研究人员提供一个交流信息的论坛。根据表观遗传基因调控和对癌症和癌症前体组织中DNA损伤的分子反应的统一主题，已经准备了科学会谈的大纲时间表。这些讲座将涵盖肿瘤抑制因子和癌基因功能、DNA甲基化导致的基因沉默、基因组印记和染色质改变、DNA修复和重组等方面的内容。有一节课将在分子流行病学的背景下讨论这些相同的主题，另外两节课将讨论乳腺癌和血液学癌症的主题。最近的发现继续揭示连接这些领域的机制，因此我们期望研究者之间的交流将产生协同的进步。

DESCRIPTION (provided by applicant): This application is for partial funding of a conference called "Cancer Genetics and Epigenetics" to be held under the auspices of the Gordon Research Conference (GRC) in mid-January 2003 at the Sheraton Harbortown, Ventura, California. This will be the fourth biennial GRC conference on this topic during a particularly exciting time for the field. Work in all areas covered by this conference is progressing at an ever-increasing pace. This makes communication between researches ever more essential. At this conference, the attendees (130 maximum) working on selected aspects of cancer research and pertinent basic genetic/epigenetic mechanisms will debate presentations on current topics, critique poster presentations, and develop informal discussions. The meeting will feature nine speaker sessions and daily poster sessions. Poster presentations, as well as more than nine of the speakers, will be chosen from the submitted abstracts. Therefore, this conference will provide a good showcase for younger investigators and late-breaking data, as well as featuring internationally renowned senior scientists. In the tradition of this conference series, there will be emphasis on formal discussion, with 15-20 minutes set aside for debate after each talk. This conference will provide a forum for exchange of information between investigators working on the molecular biology of cancer and those working on basic mechanisms of gene regulation. An outline schedule of scientific talks has been prepared based on the unifying themes of epigenetic gene regulation and the molecular responses to DNA damage in cancers and in cancer precursor tissues. These talks will cover selected aspects of tumor suppressor and oncogene function, gene silencing by DNA methylation, genomic imprinting and chromatin alterations, DNA repair and recombination. There will be one session dealing with these same topics in the setting of molecular epidemiology, and two sessions will deal with these topics in breast cancer and hematological cancers. Recent discoveries continue to uncover mechanisms linking these areas, so we expect that cross talk among investigators will yield synergistic advances.