FASEB Summer Conference--Advance in Tetraspanin Research

FASEB夏季会议——四跨膜蛋白研究进展

• 批准号: 6459254
• 负责人: MARTIN E HEMLER
• 金额: $ 0.7万
• 依托单位: FEDERATION OF AMER SOC FOR EXPER BIOLOGY
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-06-01 至 2003-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6459254
• 关键词: CD antigens; meeting /conference /symposium; membrane proteins

This application seeks partial funding for the FASEB 2002 Summer Research Conference on Tetraspanins to be held June 15- June 20, 2002 in Tucson, Arizona. This will be the second conference ever to be dedicated to this superfamily of widely expressed, multifunctional proteins. The interest in the family has been growing rapidly with new members being identified in a wide range of species including mammals, nematodes, drosophila, and Schistosomes. A few areas of recent progress include the solving of the structure for the large extracellular loop of CD81, the identification of a host of other proteins that are either tightly or loosely associated with tetraspanins, and the production of several knockout mice. More so than ever before, researchers in the field are now poised to uncover fundamental mechanisms behind the contributions of tetraspanins towards cell motility, fusion, signaling, and other function. The conference will cover recent progress in areas of relevance to infectious disease (binding of hepatitis C virus, diphtheria toxin, virus induced syncytia formation), brain function (neurite outgrowth, astrocyte, schwann cell, oligodendrocyte functions), fertility (sperm-egg fusion), development/differentiation (myogenesis, osteogenesis and hematopoiesis, bladder development), immune function (T and B cell signaling, co-stimulation, TH1/TH2 ratios, IgM production), tumor growth and metastasis (tumor suppression, metastasis promotion), and other human diseases, retinal disease, X-linked mental retardation). There has been only one previous tetraspanin conference (in July, 2000), and that was overwhelmingly successful. No other related conferences are scheduled. The meeting will follow the standard FASEB meeting format, with 9 sessions, over 4.5 days, with 3-4 major presentations in each session. Invited attendees will include a broad spectrum of clinicians, oncologists, cell and developmental biologists, immunologists, and basic biochemists and molecular biologists. Every attempt will be made to have a balanced distribution of presenters and attendees (new, established; academic, industrial; male, female; USA, other countries; etc.). With researchers from so many diverse area being brought together, common themes relevant to human pathophysiological processes should emerge. With the recent application of newly available genomic, proteomic, and genetic technologies, an abundance of new information should be forthcoming.

本申请寻求为2002年6月15日至6月20日在亚利桑那州图森市举行的FASEB 2002夏季四环素研究会议提供部分资金。这将是有史以来第二次致力于这一广泛表达的多功能蛋白质超家族的会议。随着在包括哺乳动物、线虫、果蝇和血吸虫在内的各种物种中发现新成员，人们对该家族的兴趣迅速增长。最近取得进展的几个领域包括解决CD81的大胞外环的结构，鉴定与Tetraspanins紧密或松散相关的许多其他蛋白质，以及产生几个基因敲除小鼠。该领域的研究人员现在比以往任何时候都更准备揭示Tetraspanins对细胞运动、融合、信号和其他功能的贡献背后的基本机制。会议将涵盖以下相关领域的最新进展：传染病(丙型肝炎病毒结合、白喉毒素、病毒诱导的合胞体形成)、脑功能(轴突生长、星形胶质细胞、雪旺细胞、少突胶质细胞功能)、生育(精子-卵子融合)、发育/分化(肌肉发生、成骨和造血、膀胱发育)、免疫功能(T和B细胞信号、共刺激、TH1/TH2比率、IgM产生)、肿瘤生长和转移(肿瘤抑制、转移促进)，以及其他人类疾病、视网膜疾病、X-连锁智力低下)。以前只有一次特斯帕宁会议(2000年7月)，而且取得了压倒性的成功。没有安排其他相关会议。会议将遵循标准的FASE B会议形式，分9届会议，为期4.5天，每届会议有3-4次主要报告。应邀出席者将包括广泛的临床医生、肿瘤学家、细胞和发育生物学家、免疫学家以及基础生物化学家和分子生物学家。将尽一切努力平衡演讲者和与会者的分布(新的、现有的；学术的、行业的；男性、女性；美国和其他国家；等等)。随着来自如此多不同领域的研究人员聚集在一起，与人类病理生理过程相关的共同主题应该会出现。随着最近新获得的基因组、蛋白质和基因技术的应用，大量的新信息应该会出现。