GORDON CONFERENCE ON FIBRONECTIN, INTEGRINS

纤维连接蛋白、整合素戈登会议

• 批准号: 2010806
• 负责人: MARTIN E HEMLER
• 金额: $ 0.7万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-01-26 至 1998-01-25
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2010806
• 关键词: fibronectins; integrins; meeting /conference /symposium; travel

DESCRIPTION: (Applicant's Description) Research on fibronectin and integrins has expanded greatly in the last 10-20 years. These molecules control many basic biological functions such as cell adhesion, determination of cell shape and differentiation, organ and tissue development, hematopoiesis, immune cell function, tumorigenicity and metastasis, cell migration, cytoskeletal organization, and organization of the extracellular matrix. More recently, it has become obvious that integrins collaborate with growth factors to regulate cell proliferation and apoptosis, and thus have a major involvement in cell signaling. In addition, several of the integrins, including Alpha-2b-beta-3 on platelets, alpha-5-beta-3 on tumor blood vessels, and alpha-4 integrins on immune cells, have become widely recognized as targets for therapeutic intervention. The overall importance of fibronectin and integrins is further emphasized by the results from several knockout mouse experiments. In many cases, null/null mutations have produced embryonic lethal or perinatal lethal phenotypes. The challenge for the cell adhesion field over the next several years will be to comprehend and organize the large amount of new structural information and design experiments based upon it; learn the relative biological importance of the several seemingly redundant adhesion systems; and apply the new insights to the treatment of human diseases. The 1997 Gordon Research Conference on "Fibronectin, Integrins, and Related Macromolecules" will serve as a valuable forum to present and discuss new information, identify problem areas, and plan new approaches.

描述：（申请人的描述）关于纤连蛋白和 在过去的10-20年中，整联蛋白已大大扩展。 这些分子 控制许多基本的生物学功能，如细胞粘附、决定 细胞形状和分化，器官和组织发育， 造血，免疫细胞功能，致瘤性和转移，细胞 迁移、细胞骨架组织和细胞外 矩阵 最近，很明显整合素 与生长因子一起调节细胞增殖和凋亡， 主要参与细胞信号传导。 此外， 整合素，包括血小板上的α-2b-β-3，肿瘤上的α-5-β-3 血管和免疫细胞上的α-4整合素，已经广泛地 被认为是治疗干预的目标。 全局性 的结果进一步强调了纤维连接蛋白和整合素 几次基因敲除小鼠实验 在许多情况下，无效/无效突变 产生胚胎致死或围产期致死表型。 面临的挑战 细胞粘附领域在未来几年将是理解 并组织大量的新结构信息和设计 基于它的实验;学习相对生物学的重要性， 几个看似多余的粘附系统;并将新的见解应用于 人类疾病的治疗。 1997年戈登研究会议 “纤连蛋白、整合素及相关大分子”将作为 提供和讨论新信息、确定问题 #21453;，并规划新的方法。