Matrix and Morphogenesis Conference

描述(由申请人提供)： 生物体经历形态发生以形成允许生命的结构。为 例如，在胚胎发育过程中，上皮细胞必须能够从 上皮细胞呈成纤维细胞样形态，并能迁移和增殖。 当形态发生过程出错时，细胞可以转化为 恶性表型。大量的形态发生变化是由 特定的细胞表面与细胞外基质成分相互作用。这个 已计划召开基质与形态发生会议，突出细胞- 细胞和细胞-基质通讯是形态发生中的关键角色。 会议将于4月4日在波士顿的公园广场酒店举行 2002年13日，是对生化感兴趣的科学家们的首要会议， 细胞外基质在遗传和病理上的作用 形态发生。会议涵盖了广泛的议题，包括角色 细胞外基质分子在形态发生、形态发生中的作用 发展中的系统，以及形态发生，因为它适用于癌症发生。 讲座将讨论纤维蛋白、SPARC和个体的形态发生作用 层粘连蛋白。细胞信号传递、黏附、蛋白分解和 向恶性表型的转化，将根据他们的 对形态发生的贡献。其他演讲者将讨论骨骼生成， 肌肉发生、细胞与细胞和细胞与基质的相互作用。重要的是 我们将讨论上皮-间充质的相互作用，因为它与 发展、伤口愈合和修复，以及转化的癌症表型。 此外，涉及小鼠遗传方法的研究将提交给 阐明新的基质成分的功能并支持当前的 围绕形态发生的假说。这次会议的目的是促进 这项研究中最令人兴奋和最高质量的科学的交流 促进各级科学家之间的合作。这个 会议将以宴会结束，新的和经验丰富的调查人员将在那里 坐在一起，促进讨论和网络交流。在宴会上， 约翰·霍普金斯医学院第一位女毕业生伊丽莎白·海伊博士将 感到荣幸。她曾担任《发展》杂志的主编 生物学和哈佛医学院解剖学和细胞生物学主席 部门。1984年，她当选为美国国家科学院院士。通过 促进青年科学家与演讲者的互动，约有一半 其中有杰出的女性榜样，大会致力于 鼓励初级调查员的职业发展。请拨出资金以 报销特邀演讲人、主持人、 获奖者和组织者，并支付视听费用，以及印刷和 邮寄费用。这次会议为高级官员和 初级科学家聚集并讨论最新和最先进的成果 在细胞外基质和形态发生领域。

DESCRIPTION (provided by applicant): Organisms undergo morphogenesis to develop structures that permit life. For example, during embryogenesis, epithelial cells must be able to transform from an epithelial to a fibroblast-like morphology and to migrate and proliferate. When the process of morphogenesis goes awry, cells can transform to a malignant phenotype. A large number of morphogenic changes are induced by specific cell surface interactions with extracellular matrix components. The Matrix and Morphogenesis Conference has been planned to highlight the cell- cell and cell-matrix communications that are key players in morphogenesis. The conference, which is to be held at the Park Plaza Hotel in Boston on April 13, 2002, is a premier meeting for scientists interested in the biochemical, genetic, and pathological contribution of extracellular matrix to morphogenesis. The meeting covers a broad range of topics including the role of extracellular matrix molecules in morphogenesis, morphogenesis in a variety of developing systems, and morphogenesis as it applies to carcinogenesis. Talks will cover the morphogenic roles of fibrillin, SPARC, and individual laminins. The process of cell signaling, adhesion, proteolysis, and transformation to a malignant phenotype, will be addressed in view of their contribution to morphogenesis. Other speakers will discuss skeletogenesis, myogenesis, cell-cell and cell-matrix interactions. The importance of epithelial-mesenchymal interactions will be discussed as it relates to development, wound healing and repair, and the transformed cancer phenotype. In addition, studies involving genetic approaches in mice will be presented to elucidate the function of novel matrix components and to support the current hypotheses surrounding morphogenesis. The goal of the meeting is to promote the exchange of the most exciting and highest quality science in this research area, and to facilitate collaborations between scientists at all levels. The meeting will end with a banquet where new and experienced investigators are seated together to foster discussion and networking. At the banquet, the first woman graduate of Johns Hopkins Medical School, Dr. Elizabeth Hay, will be honored. She has served as editor-in-chief of the journal Developmental Biology and as chairman of the Harvard Medical School Anatomy and Cell Biology Department. She was elected to the National Academy of Sciences in 1984. By promoting the interactions of young scientists with the speakers, about half of which are outstanding female role models, the conference endeavors to encourage the careers of junior investigators. Funds are requested to reimburse conference fees and travel expenses of invited speakers, moderators, the honoree and organizers, and to cover audiovisual charges, and printing and mailing costs. This meeting provides a unique opportunity for senior and junior scientists to gather and discuss the latest and most advanced results in the field of extracellular matrix and morphogenesis.