Models of Impulsive Behavior in Mice

说明(由申请人提供)：建议的主要目标 研究将使我们目前用来测量的三个程序 大鼠对小鼠的冲动行为及其在小鼠身上的标准化 使用参数和药物操作。第一项任务是衡量 根据动物的等待能力，使用差值表示的冲动 低速率(DRL)调度的调度。这项任务需要动物等待 在两次回应之间赚取奖励。第二行为程序措施 通过评估延迟奖励的价值而产生的冲动。此任务衡量如何 许多动物使用调整来重视延迟和/或概率奖励 金额(调整金额)程序。第三个程序通过以下方面来衡量冲动 阻止(抑制)正在进行的强势反应的能力。更大 冲动表现为较慢的停止反应时间。这三个都是 程序已经被用来描述行为过程，这些行为过程可以 无论是老鼠还是人类，冲动行为都是其基础。我们计划将其描述为 在两个近交系小鼠身上执行这些任务，这两个品系已经被 被广泛用作转基因模型开发的背景菌株，以及 已经被证明在行为上表现出明显的差异。的影响 药物将在这两个品系的小鼠身上进行测试，并与我们的结果进行比较 以前在大鼠身上观察，以测试跨物种的有效性 任务。拟议研究的一个主要目标是建立和描述 这三个程序在小鼠身上进行测试，使这些程序可以用于 未来的研究将确定个体差异的遗传基础 表现和药物对冲动行为的影响。将要执行的行为任务 在此项目中使用MICE开发的任务与使用的现有任务并行 人类和老鼠。其他利用人类进行的相关研究也在进行中。 还有老鼠。小鼠、大鼠和人类的研究结果将与 检查行为过程中的一致性，并评估 将大鼠作为人类行为的模型。拟议中的老鼠研究将使我们能够 将我们的研究扩展到冲动行为的遗传基础。

DESCRIPTION (provided by applicant): The primary objective of the proposed research is to adapt three procedures that we are currently using to measure impulsive behavior in rats to mice and to standardize these procedures in mice using parametric and pharmacological manipulations. The first task measures impulsivity in terms of the ability of animals to wait, using a differential schedule of low rate (DRL) schedule. This task requires the animal to wait between responses to earn a reward. The second behavioral procedure measures impulsivity by assessing the value of delayed rewards. This task measures how much the animals value delayed and/or probabilistic rewards using an Adjusting Amount (AdjAmt) procedure. The third procedure measures impulsivity in terms of the ability to stop (inhibit) an ongoing prepotent response. Greater impulsivity is indicated by slower stop reaction times. All three of these procedures have been used to characterize behavioral processes that may underlie impulsive behavior in both rats and humans. We plan to characterize performance on these tasks in two inbred strains of mice, which have been widely used as background strains for the development of transgenic models, and have been shown to exhibit pronounced differences in behavior. The effects of drugs will be tested in the two strains of mice and compared to results we have previously observed in rats in order to test cross species validity of the tasks. A major goal of the proposed studies is to establish and characterize these three test procedures in mice, so that the procedures can be used in future studies to identify the genetic basis of individual differences in performance and drug effects on impulsive behavior. The behavioral tasks to be developed in this project with mice are parallel to existing tasks used with humans and rats. Related studies are ongoing in other projects using humans and rats. The results of the mouse, rat and human studies will be compared to examine concordance in the behavioral processes and to assess the validity of the rat models to human behavior. The proposed studies with mice will allow us to extend our investigation to the genetic basis of impulsive behavior.