Models of Impulsive Behavior in Mice

小鼠冲动行为模型

• 批准号: 6515891
• 负责人: Jerry B Richards
• 金额: $ 15.58万
• 依托单位: STATE UNIVERSITY OF NEW YORK AT BUFFALO
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-04-01 至 2004-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6515891
• 关键词: behavior test; behavioral /social science research tag; behavioral genetics; biological models; computer data analysis; controlled environment chamber; impulsive behavior; laboratory mouse; method development; model design /development; neuropharmacologic agent; operant conditionings; psychopharmacology; reinforcer; statistics /biometry

DESCRIPTION (provided by applicant): The primary objective of the proposed research is to adapt three procedures that we are currently using to measure impulsive behavior in rats to mice and to standardize these procedures in mice using parametric and pharmacological manipulations. The first task measures impulsivity in terms of the ability of animals to wait, using a differential schedule of low rate (DRL) schedule. This task requires the animal to wait between responses to earn a reward. The second behavioral procedure measures impulsivity by assessing the value of delayed rewards. This task measures how much the animals value delayed and/or probabilistic rewards using an Adjusting Amount (AdjAmt) procedure. The third procedure measures impulsivity in terms of the ability to stop (inhibit) an ongoing prepotent response. Greater impulsivity is indicated by slower stop reaction times. All three of these procedures have been used to characterize behavioral processes that may underlie impulsive behavior in both rats and humans. We plan to characterize performance on these tasks in two inbred strains of mice, which have been widely used as background strains for the development of transgenic models, and have been shown to exhibit pronounced differences in behavior. The effects of drugs will be tested in the two strains of mice and compared to results we have previously observed in rats in order to test cross species validity of the tasks. A major goal of the proposed studies is to establish and characterize these three test procedures in mice, so that the procedures can be used in future studies to identify the genetic basis of individual differences in performance and drug effects on impulsive behavior. The behavioral tasks to be developed in this project with mice are parallel to existing tasks used with humans and rats. Related studies are ongoing in other projects using humans and rats. The results of the mouse, rat and human studies will be compared to examine concordance in the behavioral processes and to assess the validity of the rat models to human behavior. The proposed studies with mice will allow us to extend our investigation to the genetic basis of impulsive behavior.

描述（由申请人提供）：拟定研究的主要目的 研究是调整我们目前使用的三个程序， 大鼠对小鼠的冲动行为，并将这些程序在小鼠中标准化 使用参数和药理学操作。第一项任务是 根据动物等待的能力，使用微分 低速率时间表（DRL）。这项任务需要动物等待 以获得奖励。第二个行为程序测量 通过评估延迟奖励的价值来评估冲动性。这项任务衡量了 在很大程度上，动物重视使用调整的延迟和/或概率奖励 金额（金额）程序。第三个程序测量冲动， 阻止（抑制）正在进行的优势反应的能力。更大 冲动性由较慢的停止反应时间表示。所有这三 程序已经被用来描述行为过程， 是老鼠和人类冲动行为的基础我们计划描述 在两个近交系小鼠中进行这些任务的表现， 广泛用作转基因模型开发的背景菌株，和 表现出明显的行为差异。的影响 药物将在两种小鼠中进行测试，并与我们的结果进行比较。 先前在大鼠中观察到，以测试 任务拟议研究的一个主要目标是建立和表征 这三个测试程序在小鼠中，使程序可以用于 未来的研究，以确定个体差异的遗传基础， 表现和药物对冲动行为的影响。这些行为任务 在这个项目中开发的鼠标是平行的现有任务使用 人类和老鼠相关的研究正在进行中的其他项目使用人类 还有老鼠小鼠、大鼠和人类研究的结果将与 检查行为过程的一致性，并评估 老鼠的行为模式。拟议的小鼠研究将使我们能够 将我们的研究扩展到冲动行为的遗传基础。