Understanding Multiple Antibiotic Resistance in Gram Negative Bacteria

了解革兰氏阴性细菌的多重抗生素耐药性

• 批准号: 2098558
• 金额: --
• 依托单位: University of Birmingham
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2018
• 资助国家: 英国
• 起止时间: 2018 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2098558
• 关键词: Understanding; Multiple; Antibiotic; Resistance; Gram

Antibiotics have revolutionised medicine, increased life expectancy and, alongside vaccination, have led to the near eradication of many bacterial diseases. Despite this, they have been overused in the clinic, and in animals. This had led to many bacteria becoming resistant to such antibiotics. As a direct result of this, it is estimated that 10 million people will die each year due to a resistant, and therefore untreatable, infection by the year 2050. The multiple antibiotic resistance (mar) regulon plays an important role in the development of antimicrobial resistance. The mar operon encodes a global gene regulatory system that controls a vast array of genes involved in conferring antibiotic resistance. Many of these genes have been discovered but it is thought that many remain undefined. This project will attempt to uncover new gene targets of the mar operon, and therefore identify new mechanisms of antibiotic resistance. This will potentially allow new drug targets to be identified, and will help in the fight against antimicrobial resistance.

抗生素已经彻底改变了医学，增加了预期寿命，并与疫苗接种一起，导致许多细菌性疾病几乎被根除。尽管如此，它们在临床和动物中被过度使用。这导致许多细菌对这些抗生素产生耐药性。其直接结果是，据估计，到2050年，每年将有1 000万人死于耐药性感染，因此无法治愈。多药耐药（mar）调节子在耐药性的形成中起着重要作用。mar操纵子编码一个全局基因调控系统，该系统控制大量涉及赋予抗生素抗性的基因。这些基因中的许多已经被发现，但据认为，许多仍然不确定。该项目将试图发现mar操纵子的新基因靶点，从而确定抗生素耐药性的新机制。这将有可能使新的药物靶点被确定，并将有助于对抗抗生素耐药性。