CIRCULATORY CONTROL DURING EXERCISE: EFFECT OF DISEASE

运动期间的循环控制：疾病的影响

• 批准号: 6530602
• 负责人: SCOTT A SMITH
• 金额: $ 4.42万
• 依托单位: UT SOUTHWESTERN MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-03-01 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6530602
• 关键词: blood circulation; decerebration; disease /disorder model; exercise; heart failure; hypertension; laboratory rat; muscle contraction; neuroregulation; postdoctoral investigator; somatic afferent nerve; spontaneous hypertensive rat; sympathetic nervous system

DESCRIPTION (Applicant's abstract):Exercise capacity is reduced in patients with heart disease and hypertension limiting the therapeutic value of its prescription. The long-term goal of this proposal is to understand circulatory control during exercise mediated by intramuscular somatosensory input in chronic disease. The first objective is to develop a reproducible exercise model in which cardiovascular disease is readily induced. A decerebrate rat preparation will be used and the effect of mechanically and metabolically-sensitive hindlimb afferent activity on circulatory control will be investigated. The second objective is to characterize alterations in cardiovascular control during exercise after the development of heart failure. Myocardial infarction will be induced in rats via coronary artery ligation. Changes in heart rate, blood pressure, and renal sympathetic nerve activity will be measured in response to static muscle contraction and passive muscle stretch after decerebration. The third objective is to identify changes in circulatory regulation during exercise in hypertension using the methods presented above. A genetically engineered strain of spontaneously hypertensive rats will be employed and responses compared to a control group of normotensive rats. Results from these experiments will not only describe a novel animal preparation for the study of cardiovascular control by intramuscular neural mechanisms but will lead to an improved understanding of circulatory regulation during exercise after the manifestation of clinical pathologies.

描述（申请人摘要）：患者运动能力下降 心脏病和高血压限制了其治疗价值 处方。该提案的长期目标是了解循环系统 运动过程中通过肌内体感输入介导的控制 慢性疾病。第一个目标是开发可重复的练习 容易诱发心血管疾病的模型。一只去大脑的老鼠 将使用制剂以及机械和 对循环控制的代谢敏感的后肢传入活动将 被调查。第二个目标是描述变化的特征 心力衰竭发生后运动期间的心血管控制。 通过冠状动脉结扎在大鼠中诱导心肌梗塞。 心率、血压和肾交感神经活动的变化 将根据静态肌肉收缩和被动肌肉进行测量 去脑后拉伸。第三个目标是识别变化 使用方法调节高血压运动期间的循环 上面介绍的。一种经过基因工程改造的自发性高血压菌株 将使用大鼠并与血压正常的对照组进行比较 老鼠。这些实验的结果不仅会描述一种新的动物 为肌内神经控制心血管研究做准备 机制，但将导致对循环调节的更好理解 临床病理表现后运动期间。

项目成果

Role of the exercise pressor reflex in rats with dilated cardiomyopathy.

运动升压反射在扩张型心肌病大鼠中的作用。

• DOI: 10.1161/01.cir.0000084538.40542.56
• 发表时间: 2003
• 期刊: Circulation.
• 作者: Smith,ScottA;Mammen,PradeepPA;Mitchell,JereH;Garry,MaryG
• 通讯作者: Garry,MaryG