CIRCULATORY CONTROL DURING EXERCISE: EFFECT OF DISEASE

运动期间的循环控制：疾病的影响

• 批准号: 6294313
• 负责人: SCOTT A SMITH
• 金额: $ 3.48万
• 依托单位: UT SOUTHWESTERN MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-03-01 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6294313
• 关键词: blood circulation; decerebration; disease /disorder model; exercise; heart failure; hypertension; laboratory rat; muscle contraction; neuroregulation; postdoctoral investigator; somatic afferent nerve; spontaneous hypertensive rat; sympathetic nervous system

DESCRIPTION (Applicant's abstract):Exercise capacity is reduced in patients with heart disease and hypertension limiting the therapeutic value of its prescription. The long-term goal of this proposal is to understand circulatory control during exercise mediated by intramuscular somatosensory input in chronic disease. The first objective is to develop a reproducible exercise model in which cardiovascular disease is readily induced. A decerebrate rat preparation will be used and the effect of mechanically and metabolically-sensitive hindlimb afferent activity on circulatory control will be investigated. The second objective is to characterize alterations in cardiovascular control during exercise after the development of heart failure. Myocardial infarction will be induced in rats via coronary artery ligation. Changes in heart rate, blood pressure, and renal sympathetic nerve activity will be measured in response to static muscle contraction and passive muscle stretch after decerebration. The third objective is to identify changes in circulatory regulation during exercise in hypertension using the methods presented above. A genetically engineered strain of spontaneously hypertensive rats will be employed and responses compared to a control group of normotensive rats. Results from these experiments will not only describe a novel animal preparation for the study of cardiovascular control by intramuscular neural mechanisms but will lead to an improved understanding of circulatory regulation during exercise after the manifestation of clinical pathologies.

描述（申请人摘要）：患者的运动能力降低 心脏病和高血压限制了其治疗价值， 处方.本提案的长期目标是了解循环 肌肉内体感输入介导的运动控制 慢性病第一个目标是发展一种可重复的做法 容易诱发心血管疾病的模型。一只去大脑的老鼠 准备将使用和机械和 代谢敏感的后肢传入活动对循环控制将 追究第二个目标是描述 心血管控制在运动后心力衰竭的发展。 将通过冠状动脉结扎在大鼠中诱导心肌梗死。 心率、血压和肾交感神经活动的变化 将在静态肌肉收缩和被动肌肉收缩时测量 去大脑后伸展第三个目标是确定 高血压患者运动循环调节的方法 上面介绍的。自发性高血压的基因工程菌株 将使用大鼠并将反应与血压正常的对照组进行比较。 大鼠这些实验的结果将不仅描述一种新的动物 肌内神经调节心血管作用研究用制剂 机制，但将导致更好地了解循环调节 在临床病理表现后的运动期间。