Molecular Studies of Human All
Molecular Studies of Human All
批准号:
6360394
负责人:
LINDA M BOXER
金额:
$22.33万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2001
资助国家:
美国
项目状态:
已结题
起止时间:
2001-07-16 至 2006-06-30
中文摘要
描述(由申请人提供):分子细胞遗传学研究
为确定儿童ALL的预后提供了新的信息。
参与主要染色体易位的基因已经被
确定,和一些研究的特点,所产生的融合
proteins.目前尚不清楚融合蛋白如何参与细胞的增殖过程。
然而,白血病发生。虽然对不同易位的了解,
ALL可用于预测治疗反应、反应异质性
存在于ALL的细胞遗传学亚群中。我们假设这个基因
表达分析将能够区分不同的细胞遗传学
儿科B细胞ALL的亚组。此外,我们将确定是否
可以在ALL的几个易位组中鉴定出亚组
以及是否可以获得关于预后的进一步信息。我们将研究
是否可以通过基因表达分析鉴定“复发标记”,
易位亚型内的复发ALL样本。有证据表明,在
体外药物敏感性与体内对药物的反应相关
无事件生存。微阵列分析将用于跟踪
在敏感性和敏感性细胞中,
耐药ALL细胞进一步的研究将被设计来识别基因,
与融合基因的表达直接相关,并且在
白血病发生的过程
1.儿童急性淋巴细胞白血病基因表达谱的分析与比较
t(9;22)、t(1;19)、t(4; 11)、t(11;19)和t(12;21)的样本。2.相关性
t(1;19)和t(12;21)ALL组中的基因表达模式,
预后和复发。3.确定在小鼠中基因表达的变化
敏感和耐药的ALL细胞对化疗药物的反应
剂. 4.融合蛋白特异性事件的鉴定和融合蛋白的研究
细胞系中的重要基因和途径
英文摘要
DESCRIPTION (provided by applicant): Molecular cytogenetic studies have
provided new information for the determination of prognosis in pediatric ALL.
The genes involved in the major chromosomal translocations have been
identified, and a number of studies have characterized the resulting fusion
proteins. It is not known how the fusion proteins contribute to the process of
leukemogenesis, however. Although knowledge of the different translocations in
ALL is useful for predicting response to treatment, heterogeneity of response
exists within the cytogenetic subgroups of ALL. We hypothesize that gene
expression analysis will be able to distinguish among the different cytogenetic
subgroups of pediatric B cell ALL. In addition, we will determine whether
subgroups can be identified within several of the translocation groups of ALL
and whether further information on prognosis can be obtained. We will examine
whether a "relapse signature" can be identified by gene expression analysis of
relapsed ALL samples within a translocation subtype. Evidence suggests that in
vitro drug sensitivity correlates with in vivo response to the drug as measured
by event-free survival. Microarray analysis will be used to follow changes in
gene expression in response to a chemotherapeutic agent in both sensitive and
resistant ALL cells. Further studies will be designed to identify genes that
are directly correlated with expression of the fusion gene and important in the
process of leukemogenesis.
1. Analysis and comparison of the gene expression profiles in pediatric ALL
samples with t(9;22), t(1;19), t(4;ll), t(11;19), and t(12;21). 2. Correlation
of gene expression patterns within the t(1;19) and t(12;21) ALL groups with
prognosis and with relapse. 3. Determination of changes in gene expression in
ALL cells, both sensitive and resistant, in response to chemotherapeutic
agents. 4. Identification of fusion protein-specific events and studies of
important genes and pathways in cell line
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科研奖励(0)
会议论文
Activation of BCL-2 in Hematologic Malgnancies
-
批准号:7483462
-
项目类别:
-
资助金额:$29.49万
-
财政年份:2007
-
负责人:LINDA M BOXER
-
依托单位:
Training Program in Investigative Hematology
-
批准号:7902054
-
项目类别:
-
资助金额:$9.91万
-
财政年份:2001
-
负责人:LINDA M BOXER
-
依托单位:
Training Program in Investigative Hematology
-
批准号:6785381
-
项目类别:
-
资助金额:$26.45万
-
财政年份:2001
-
负责人:LINDA M BOXER
-
依托单位:
TRAINING PROGRAM IN INVESTIGATIVE HEMATOLOGY
-
批准号:6906461
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项目类别:
-
资助金额:$4.95万
-
财政年份:2001
-
负责人:LINDA M BOXER
-
依托单位:
Training Program in Investigative Hematology
-
批准号:7486791
-
项目类别:
-
资助金额:$26.28万
-
财政年份:2001
-
负责人:LINDA M BOXER
-
依托单位:
Training Program in Investigative Hematology
-
批准号:7280300
-
项目类别:
-
资助金额:$26.28万
-
财政年份:2001
-
负责人:LINDA M BOXER
-
依托单位:
Molecular Studies of Human All
-
批准号:6604226
-
项目类别:
-
资助金额:$22.51万
-
财政年份:2001
-
负责人:LINDA M BOXER
-
依托单位:
Training Program in Investigative Hematology
-
批准号:7067054
-
项目类别:
-
资助金额:$26.77万
-
财政年份:2001
-
负责人:LINDA M BOXER
-
依托单位:
Molecular Studies of Human All
-
批准号:6751585
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项目类别:
-
资助金额:$22.6万
-
财政年份:2001
-
负责人:LINDA M BOXER
-
依托单位:
Training Program in Investigative Hematology
-
批准号:7668485
-
项目类别:
-
资助金额:$11.5万
-
财政年份:2001
-
负责人:LINDA M BOXER
-
依托单位:
Molecular Studies of Human All
-
批准号:6515197
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项目类别:
-
资助金额:$22.32万
-
财政年份:2001
-
负责人:LINDA M BOXER
-
依托单位:
CONTROL OF C-MYC TRANSCRIPTION IN AGGRESSIVE LYMPHOMAS
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批准号:6102161
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项目类别:
-
资助金额:$21.01万
-
财政年份:1999
-
负责人:LINDA M BOXER
-
依托单位:
CONTROL OF C-MYC TRANSCRIPTION IN AGGRESSIVE LYMPHOMAS
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批准号:6269176
-
项目类别:
-
资助金额:$25.98万
-
财政年份:1998
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负责人:LINDA M BOXER
-
依托单位:
CONTROL OF C-MYC TRANSCRIPTION IN AGGRESSIVE LYMPHOMAS
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批准号:6236697
-
项目类别:
-
资助金额:$25.1万
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财政年份:1997
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负责人:LINDA M BOXER
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依托单位:
REGULATION OF EXPRESSION OF C-MYB IN LEUKEMIAS
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批准号:6173286
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项目类别:
-
资助金额:$19.55万
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财政年份:1996
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负责人:LINDA M BOXER
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依托单位:
REGULATION OF EXPRESSION OF C-MYB IN LEUKEMIAS
-
批准号:2733270
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项目类别:
-
资助金额:$19.07万
-
财政年份:1996
-
负责人:LINDA M BOXER
-
依托单位:
REGULATION OF EXPRESSION OF C-MYB IN LEUKEMIAS
-
批准号:2010192
-
项目类别:
-
资助金额:$17.78万
-
财政年份:1996
-
负责人:LINDA M BOXER
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依托单位:
CONTROL OF C MYC TRANSCRIPTION IN HIGH GRADE LYMPHOMAS
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批准号:2871876
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项目类别:
-
资助金额:$18.9万
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财政年份:1996
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负责人:LINDA M BOXER
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依托单位:
CONTROL OF C MYC TRANSCRIPTION IN HIGH GRADE LYMPHOMAS
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批准号:2330957
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项目类别:
-
资助金额:$17.87万
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财政年份:1996
-
负责人:LINDA M BOXER
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依托单位:
CONTROL OF MYC TRANSCRIPTION IN HIGH GRADE LYMPHOMA
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批准号:6263170
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项目类别:
-
资助金额:$24.57万
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财政年份:1996
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负责人:LINDA M BOXER
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依托单位:
海外基金