Optical Measurement of Choroid to Photoreceptor Distance

脉络膜到感光器距离的光学测量

• 批准号: 6550183
• 负责人: DANIEL R NEAL
• 金额: $ 12.39万
• 依托单位: WAVEFRONT SCIENCES, INC.
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-30 至 2004-03-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6550183
• 关键词: biomedical automation; choroid uvea; clinical research; diagnosis design /evaluation; eye disorder diagnosis; eye refractometry; human subject; measurement; method development; optics; retina circulation; visual photoreceptor

DESCRIPTION (provided by applicant): Although the average accuracy of autorefractors is very good, they still cannot be reliably used to write eyeglass prescriptions because about 20 percent of patients will be measured differently by subjective refraction by at least 0.5 diopters. Further, the patients that are measured differently have the same error on autorefractors made by many different manufacturers. This indicates that there is some structural difference in those eyes. We hypothesize that the significant structural difference is that the spacing between the photoreceptors to the choroid blood supply is different in those patients relative to the general population. We propose a method to measure the photoreceptor to choroid spacing and a method to use that parameter to improve the calculated spherical equivalent power on those patients. Means are also provided to test the hypothesis that the Stiles Crawford effect is responsible for the difference in autorefractions versus subjective refractions. Expected benefits of this research include improved and earlier detection of various retinal pathologies, potential benefits for diabetic patients and others. Medical practice is anticipated to benefit through advancements in automated refraction techniques.

描述（申请人提供）：虽然自动验光仪的平均准确度非常好，但仍然不能可靠地用于开具眼镜处方，因为大约 20% 的患者会通过主观验光测量出至少 0.5 屈光度的差异。此外，不同制造商生产的自动验光仪对进行不同测量的患者具有相同的误差。这表明这些眼睛存在一些结构差异。我们假设显着的结构差异在于这些患者的光感受器与脉络膜血液供应之间的间距相对于一般人群是不同的。我们提出了一种测量光感受器与脉络膜间距的方法，以及一种使用该参数来改进这些患者的计算球面等效功率的方法。还提供了方法来检验斯泰尔斯·克劳福德效应导致自动验光与主观验光差异的假设。这项研究的预期好处包括改进和早期检测各种视网膜病变，为糖尿病患者和其他人带来潜在好处。预计医疗实践将受益于自动验光技术的进步。

项目成果

Differences between wavefront and subjective refraction for infrared light.

红外光的波前和主观折射之间的差异。

• DOI: 10.1097/opx.0000000000000370
• 发表时间: 2014
• 期刊: Optometry and vision science : official publication of the American Academy of Optometry
• 作者: Teel,DanielleFW;Jacobs,RobertJ;Copland,James;Neal,DanielR;Thibos,LarryN
• 通讯作者: Thibos,LarryN

Design and validation of an infrared Badal optometer for laser speckle.

用于激光散斑的红外 Badal 验光计的设计和验证。

• DOI: 10.1097/opx.0b013e3181852742
• 发表时间: 2008
• 期刊: Optometry and vision science : official publication of the American Academy of Optometry
• 作者: Teel,DanielleFW;Copland,RJames;Jacobs,RobertJ;Wells,Thad;Neal,DanielR;Thibos,LarryN
• 通讯作者: Thibos,LarryN