Shack-Hartmann Corneal Topographer and Aberrometer

本项目的长期目标是设计、制造和销售一种眼科仪器，该仪器使用波前传感技术同时测量人眼的角膜地形图、角膜像差和全眼光学像差。通过这些测量，我们的仪器将提供前角膜、整个眼睛和（通过推断）晶状体透镜的折射特性的完整描述。这种光学描述不仅包括近视、远视和散光等常规屈光不正， 通过当今的验光仪和角膜地形图仪测量，而且还将确定限制视觉质量的不规则的高阶光学像差。该项目是Wavefront Sciences，Inc.和Quarryment Optical，Inc.我们全新的多功能 仪器将围绕全眼科分析系统（COAS）的核心技术构建，COAS是目前由Wavefront Sciences，Inc.销售的临床全眼像差仪。在第二阶段的第一年，我们建议为COAS增加新的功能，以同时测量角膜地形图和角膜像差。Quarrymen Optical，Inc.通过使用Shack-Hartmann波前的核心技术构建和验证原型角膜地形图仪/像差仪，证明了这种多用途仪器在I期的可行性 传感器开发与以前的STTR支持。在第二年，我们将使用临床正常和异常人眼对我们的原型仪器进行实验验证和临床评估。我们的组合仪器将有助于提供波前引导处方，用于使用眼间透镜、角膜屈光手术或隐形眼镜进行像差矫正。长期的好处将是通过改善对眼睛光学缺陷的诊断和治疗来改善患者护理。

The long-term objective of our project is to design, build, and market an ophthalmic instrument that simultaneously measures corneal topography, corneal aberrations, and whole-eye optical aberrations of the human eye using wavefront sensing technology. From these measurements our instrument will provide a complete description of the refractive properties of the anterior cornea, the whole eye, and (by inference) the crystalline lens. This optical description will include not only the routine refractive errors of myopia, hyperopia, and astigmatism normally measured by present day optometers and corneal topographers, but will also determine the irregular, higher-order optical aberrations that limit the quality of vision. This project is a joint venture of Wavefront Sciences, Inc. and Quarryment Optical, Inc. Our new, multipurpose instrument will be built around core technology of the Complete Ophthalmic Analysis System (COAS), a clinical whole-eye aberrometer currently marketed by Wavefront Sciences, Inc. In year I of this Phase II project we propose to add new functionallity to COAS for simultaneously measuring corneal topograhphy and corneal aberrometry. Quarrymen Optical, Inc. demonstrated feasibilty of such a multi-purpose instrument in Phase-I by building and validataing a prototype corneal topographer/aberrometer using core technology of a Shack-Hartmann wavefront sensor developed with previous STTR support. In year 2 we will experimentally validate and clinically evaluate our prototype instrument using clinically normal and abnormal human eyes. Our combined instrument will help provide wavefront-guided prescriptions for aberration corrections using inter-ocular lenses, corneal refractive surgery, or contact lenses. The long-term benefits will be improved patient care through improved diagnosis and treatment of optical defects of eyes.