SURFACE-CHARGED HA/TIO2 ULTRATHIN FILM

表面带电 HA/TIO2 超薄膜

• 批准号: 6550399
• 负责人: JIANKAI LIU
• 金额: $ 10万
• 依托单位: CHEMAT TECHNOLOGY, INC.
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-01 至 2003-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6550399
• 关键词: biomaterial development /preparation; biomaterial interface interaction; cell adhesion; dental implants; hydroxyapatites; medical implant science; method development; osteoblasts; surface coating; surface property; titanium

DESCRIPTION (provided by applicant): A functionally graded HA/TiO2 ultrathin film (tens manometers), with a charged surface, on pure titanium Dental implant will be developed using functionally graded /self-assembled sol-gel coating process. A three-layer functionally graded coating structure which consists of sub-layers of 100%Ti - 0% HA, 50%Ti - 50% HA, and 0%Ti - 100%HA enhance the adherence of HA film to Titanium implant surface. Ionic self-assembled process provides ultrathin coating (tens nm or less) for each layer with positive/negative charged surface, this induces an early and accelerated osteoblast adhesion thereby reducing the healing time during implantation due to the maintenance of the rough surfaces of the commercial titanium implants and electrically polarization. Sol-gel low temperature processing yields pure HA coating, which reduce the dissolution of non-HA phosphate calcium in body solution. These advantages should benefit the patients with inadequate bones or significant load bearing implant designs, for whom no definite treatments are available.

描述（由申请人提供）：将使用功能梯度/自组装溶胶-凝胶涂层工艺在纯钛牙科种植体上开发具有带电表面的功能梯度HA/TiO 2纳米薄膜（数十纳米）。由100%Ti -0%HA、50%Ti -50%HA和0%Ti - 100%HA亚层组成的三层功能梯度涂层结构增强了HA膜与钛植入物表面的粘附。离子自组装过程为具有正/负电荷表面的每一层提供了致密涂层（数十nm或更少），这诱导了早期和加速的成骨细胞粘附，从而由于维持了商业钛植入物的粗糙表面和电极化而缩短了植入过程中的愈合时间。溶胶-凝胶低温处理产生纯HA涂层，其减少非HA磷酸钙在体溶液中的溶解。这些优点应使骨量不足或具有显著承重植入物设计的患者受益，这些患者没有明确的治疗方法。