3D Image Guided Patient System for Stereotactic Radioth.

用于立体定向放射的 3D 图像引导患者系统。

• 批准号: 6443147
• 负责人: PING ZHUANG
• 金额: $ 10万
• 依托单位: GENEX TECHNOLOGIES, INC.
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-08-15 至 2003-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6443147
• 关键词: bioimaging /biomedical imaging; biomedical equipment development; clinical research; computed axial tomography; computer assisted patient care; computer program /software; human subject; image processing; imaging /visualization /scanning; mathematical model; patient monitoring device; phantom model; radiation therapy; stereotaxic techniques; video recording system

DESCRIPTION (provided by applicant): With rapid development in 3D conformal radiation therapy and stereotactic radiotherapy, which tends to treat small and highly tailored clinical targets with very high doses, increasingly stringent setup accuracy become more important. Currently, many researches in early tumor detection use imaging techniques such as CT, MRI, and SPECT, treatment plan optimization using inverse planning, and beam management using IMRT and SRT. There are lack of development in patient refixation technique. The primary objective of the SBIR effort proposed herein is to develop a novel patient refixation technique feasible for daily treatment of fractionated radiotherapy. The technique can achieve a high accuracy and precision within 1-mm by using a novel high-speed three-dimensional (3D) video camera. The precise 3D-surface images of patient can be captured following the patient positioned on the treatment couch. The surface images are compared with the reference 3D image that is created from the previous CT scans or 3D-video image with the patient in the planned treatment position. The 3D surface fitting and frame subtraction techniques will generate quantitative parameters regarding patient?s positioning error in all six degree-of-freedom, facilitating the re-position adjustment. Because the video image is acquired instantly, this frame-less patient refixation system also provides a solution for the real-time detection and correction of patient motion relative to the treatment machine in a single fraction. In the proposed Phase 1 effort, we will (1) Design an accurate patient refixation system using a 3D video camera; (2) Build prototype hardware of the 3D video camera and assess the clinical feasibility; (3) Develop the proposed 3D image subtraction and comparison algorithms to unfold patient positioning error; (4) Improve the software tools to interactively visualize and rapidly quantify 3D positioning errors; and (5) Perform patient reposition experiments. PROPOSED COMMERCIAL APPLICATION: The proposed 3D imaging technology adds one more dimension (literally and figuratively) to fractional radiation treatment repositioning applications, and will lead to a new generation of commercial products of patient repositioning systems for radiotherapy. With hundreds of radiation treatment machines in USA and many more in Europe, the market for a clinically acceptable 3D-camera-based refixation system is significant. If it succeeds, it will have a significant impact on biomedical research and will revolutionize many current practices in rafixation during cancer treatment. It would find utility in reconstructive surgery due to cancer, body deformities, orthotics, rehabilitation, resident training and education.

描述（申请人提供）：在三维适形领域发展迅速

项目成果

Clinical results of a pilot study on stereovision-guided stereotactic radiotherapy and intensity modulated radiotherapy.

立体视觉引导立体定向放射治疗和调强放射治疗试点研究的临床结果。

• DOI: 10.1177/153303461000900609
• 发表时间: 2010
• 期刊: Technology in cancer research & treatment
• 影响因子: 2.8
• 作者: Li,Shidong;Kleinberg,LawrenceR;Rigamonti,Daniele;WharamJr,MoodyD;Rashid,Abdul;Jackson,Juan;Djajaputra,David;He,Shenjen;Creasey,Tunisia;DeWeese,TheodoreL
• 通讯作者: DeWeese,TheodoreL