Laser Delivery System for Improved Thermal Therapy

用于改善热疗的激光传输系统

• 批准号: 6484312
• 负责人: Ashok Gowda
• 金额: $ 10万
• 依托单位: BIOTEX, INC.
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-07-09 至 2003-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6484312
• 关键词: bioengineering /biomedical engineering; biomedical equipment development; dogs; fiber optics; laser therapy; metastasis; neoplasm /cancer thermotherapy; photocoagulation therapy; radiation dosage

DESCRIPTION (provided by applicant): The liver and brain are the most common sites of metastatic tumors. At the time of death, approximately two-thirds of patients with colorectal cancer have liver metastases. In addition approximately 83 percent of all brain cancers will be diagnosed as metastatic tumors. In this work, we propose to develop an improved laser thermal therapy system for treatment of cancer metastases. The BioTex Cooled Laser Delivery System will combine a novel cooled applicator and low power diode laser system. The proposed innovative applicator is designed to remove heat from both the fiber optic and tissue in contact with the applicator surface while maintaining a low profile and thereby causing less damage to normal tissue during placement. A reduction in temperature of the fiber optic applicator and surrounding tissue during laser irradiation will increase the overall light penetration into tissue, allow for longer exposure times, and produce larger photocoagulative lesions in a far safer manner than previously possible. Combining the novel applicator with a low-power diode laser that is reliable, convenient, and easy to use should greatly increase the overall appeal for laser therapy in the treatment of solid tumors. PROPOSED COMMERCIAL APPLICATION: This research is specifically targeted towards the development of a safer, more efficient minimally invasive treatment for metastatic tumors. Laser interstitial thermal therapy offers a unique opportunity for minimally invasive destruction of such tumors. A safer more efficient laser system would significantly increase the number of tumors amenable to laaser therapy and therefore result in a significant potential for commercial success.

描述(申请人提供)：最常见的是肝脏和大脑 转移瘤的部位。在死亡时，大约三分之二的人 结直肠癌患者有肝转移。此外 大约83%的脑癌将被诊断为转移性 肿瘤。在这项工作中，我们建议开发一种改进的激光热疗。 癌症转移治疗系统。BioTex冷却激光传输 该系统将结合一种新型的制冷加速器和低功率半导体激光系统。 拟议的创新喷头旨在从两个 与施加器表面接触的光纤和组织，同时保持 低调，从而对正常组织造成较少的损害 放置。光纤施加器温度的降低以及 在激光照射过程中，周围组织将增加整体光线 渗透到组织中，允许更长的曝光时间，并产生更大的 以一种比以前安全得多的方式进行光凝损伤。 将新型涂布器与低功率可靠的半导体激光器相结合， 方便，易于使用，应该会大大增加整体吸引力 激光疗法在实体瘤治疗中的应用 拟议的商业应用：这项研究的目标是开发一种更安全、更有效的转移性肿瘤微创治疗方法。激光间质热疗为这类肿瘤的微创治疗提供了独特的机会。一个更安全、更有效的激光系统将显着增加激光治疗的肿瘤数量，从而带来巨大的商业成功潜力。