Laser Delivery System for Improved Thermal Therapy

用于改善热疗的激光传输系统

• 批准号: 6484312
• 负责人: Ashok Gowda
• 金额: $ 10万
• 依托单位: BIOTEX, INC.
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-07-09 至 2003-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6484312
• 关键词: bioengineering /biomedical engineering; biomedical equipment development; dogs; fiber optics; laser therapy; metastasis; neoplasm /cancer thermotherapy; photocoagulation therapy; radiation dosage

DESCRIPTION (provided by applicant): The liver and brain are the most common sites of metastatic tumors. At the time of death, approximately two-thirds of patients with colorectal cancer have liver metastases. In addition approximately 83 percent of all brain cancers will be diagnosed as metastatic tumors. In this work, we propose to develop an improved laser thermal therapy system for treatment of cancer metastases. The BioTex Cooled Laser Delivery System will combine a novel cooled applicator and low power diode laser system. The proposed innovative applicator is designed to remove heat from both the fiber optic and tissue in contact with the applicator surface while maintaining a low profile and thereby causing less damage to normal tissue during placement. A reduction in temperature of the fiber optic applicator and surrounding tissue during laser irradiation will increase the overall light penetration into tissue, allow for longer exposure times, and produce larger photocoagulative lesions in a far safer manner than previously possible. Combining the novel applicator with a low-power diode laser that is reliable, convenient, and easy to use should greatly increase the overall appeal for laser therapy in the treatment of solid tumors. PROPOSED COMMERCIAL APPLICATION: This research is specifically targeted towards the development of a safer, more efficient minimally invasive treatment for metastatic tumors. Laser interstitial thermal therapy offers a unique opportunity for minimally invasive destruction of such tumors. A safer more efficient laser system would significantly increase the number of tumors amenable to laaser therapy and therefore result in a significant potential for commercial success.

描述（由申请人提供）：肝脏和大脑是最常见的 转移性肿瘤的部位。死亡时，大约三分之二的人 患有结肠直肠癌的患者具有肝转移。此外 大约83%的脑癌将被诊断为转移性的， 肿瘤的在这项工作中，我们建议开发一种改进的激光热疗法， 用于治疗癌症转移系统。BioTex冷却激光输送系统 系统将结合一种新型的冷却施用器和低功率二极管激光系统联合收割机。 所提出的创新涂抹器被设计成从两个表面去除热量， 光纤和组织与施加器表面接触， 低轮廓，从而在手术过程中对正常组织造成较小的损伤， 安置光纤施加器的温度降低， 在激光照射期间周围组织将增加整体光 穿透组织，允许更长的暴露时间，并产生更大的 比以前可能的方式更安全的光凝损伤。 将新型施用器与可靠的低功率二极管激光器相结合， 方便，易于使用，应大大增加整体吸引力， 激光治疗在实体瘤治疗中的应用 拟定商业应用：这项研究专门针对发展一种更安全，更有效的转移性肿瘤微创治疗。 激光间质热疗法为这种肿瘤的微创破坏提供了独特的机会。 一个更安全、更有效的激光系统将大大增加适合激光治疗的肿瘤数量，因此具有巨大的商业成功潜力。