Laser Delivery System for Improved Thermal Therapy

用于改善热疗的激光传输系统

• 批准号: 6484312
• 负责人: Ashok Gowda
• 金额: $ 10万
• 依托单位: BIOTEX, INC.
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-07-09 至 2003-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6484312
• 关键词: bioengineering /biomedical engineering; biomedical equipment development; dogs; fiber optics; laser therapy; metastasis; neoplasm /cancer thermotherapy; photocoagulation therapy; radiation dosage

DESCRIPTION (provided by applicant): The liver and brain are the most common sites of metastatic tumors. At the time of death, approximately two-thirds of patients with colorectal cancer have liver metastases. In addition approximately 83 percent of all brain cancers will be diagnosed as metastatic tumors. In this work, we propose to develop an improved laser thermal therapy system for treatment of cancer metastases. The BioTex Cooled Laser Delivery System will combine a novel cooled applicator and low power diode laser system. The proposed innovative applicator is designed to remove heat from both the fiber optic and tissue in contact with the applicator surface while maintaining a low profile and thereby causing less damage to normal tissue during placement. A reduction in temperature of the fiber optic applicator and surrounding tissue during laser irradiation will increase the overall light penetration into tissue, allow for longer exposure times, and produce larger photocoagulative lesions in a far safer manner than previously possible. Combining the novel applicator with a low-power diode laser that is reliable, convenient, and easy to use should greatly increase the overall appeal for laser therapy in the treatment of solid tumors. PROPOSED COMMERCIAL APPLICATION: This research is specifically targeted towards the development of a safer, more efficient minimally invasive treatment for metastatic tumors. Laser interstitial thermal therapy offers a unique opportunity for minimally invasive destruction of such tumors. A safer more efficient laser system would significantly increase the number of tumors amenable to laaser therapy and therefore result in a significant potential for commercial success.

描述（申请人提供）：肝脏和大脑是最常见的 转移性肿瘤部位。在死亡时，大约三分之二 结直肠癌患者患有肝转移。此外 大约83％的大脑癌症将被诊断为转移 肿瘤。在这项工作中，我们建议开发改进的激光热疗法 治疗癌症转移的系统。 Biotex冷却激光输送 系统将结合新型冷却的涂抹器和低功率二极管激光系统。 拟议的创新涂抹器旨在消除两者的热量 保持光纤和组织与施加器表面接触 低调，从而在正常组织中造成更少的损害 放置。光纤涂药器的温度降低和 激光照射期间周围的组织将增加整体光 渗透到组织中，允许更长的暴露时间，并产生更大的 光凝病变的方式远不止以前。 将新颖的涂抹器与可靠的低功率二极管激光相结合， 方便且易于使用的应大大提高整体吸引力 激光治疗实体瘤。 拟议的商业应用：这项研究专门针对开发用于转移性肿瘤的更安全，更有效的微创治疗方法。 激光间质热疗法为这种肿瘤的微创破坏提供了独特的机会。 更安全的更有效的激光系统将显着增加适合Laaser治疗的肿瘤数量，从而产生商业成功的巨大潜力。