Local Hyperthermia Catheter for Enhanced Ablation and Cancer Therapy

用于增强消融和癌症治疗的局部热疗导管

基本信息

批准号：
7908551
负责人：
Ashok Gowda
金额：
$ 15.11万
依托单位：
BIOTEX, INC.
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-09-01 至 2012-02-28
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7908551
关键词：
Ablation Animal Model Animals Antineoplastic Agents Applications Grants Area Benign Blood Blood Cells Blood Vessels Blood flow Cancerous Catheters Clinic Clinical Clinical Trials Deposition Development Devices Encapsulated Engineering Family suidae Fever Goals Heating Human Interventional radiology Kidney Lasers Lead Liposomes Liver Local Hyperthermia Methodology Methods Modeling Normal tissue morphology Organ Organ Temperatures Performance Pharmaceutical Preparations Phase Physiological Pilot Projects Procedures Process Protocols documentation Radiation Radiofrequency Interstitial Ablation Regional Chemotherapy Research Rest Small Business Innovation Research Grant Solid Neoplasm Solutions Source Specialist Structure System Technology Temperature Testing Therapeutic Embolization Thermal Ablation Therapy Time Tissue Sample Tissues To specify Work base cancer therapy chemotherapy design dosimetry improved interstitial minimally invasive models and simulation novel operation prototype public health relevance radiologist tumor

项目摘要

DESCRIPTION (provided by applicant): The goal of this Phase I SBIR Grant Proposal is to develop a new device and methodology for local elevation of a target tissue's temperature prior to a planned thermal ablation, a process we've dubbed "hyperablation". In preliminary work we demonstrated that raising the pre-treated temperature of a target tissue by 100C resulted in a 60% increase in volumetric ablation size. Others have shown the benefits of embolization or other methods to decrease convective cooling from blood flow prior to an ablation procedure. The proposed hyperablation device would provide a unique way to accomplish both strategies and should lead to a significant increase in thermal ablation efficiency. Application of this technology may go beyond ablation and prove useful in a number of areas where hyperthermia is being investigated such as heat- activated liposomal chemotherapy, regional chemotherapy, and hyperthermia-enhanced radiation procedures. We will seek input from clinical collaborators and perform modeling simulations to guide the design of the hyperthermia catheter. We will source materials, fabricate prototypes, and test the device in a benchtop setup using physiologic conditions and tissue samples. Finally, we will work with clinical experts in interventional radiology to test the device in a large animal model and evaluate the performance and potential benefits of this treatment approach in the context of thermal ablation in the liver. At the end of this project, we will have determined the feasibility of creating local hyperthermia with this device and understand the potential benefits and applications for this approach. PUBLIC HEALTH RELEVANCE: The goal of this Phase I SBIR Grant proposal is to develop a novel catheter technology capable of inducing local hyperthermia and halting blood flow prior to an ablation procedure. The system will be useful for enhancing ablation zone size and may find application with other chemotherapy and radiation based protocols. This proposal is focused on design, fabrication, and testing of a prototype device in benchtop and pilot animal studies

描述（由申请人提供）：I阶段I SBIR赠款提案的目的是在计划的热消融之前开发一种新的设备和方法，用于局部升高目标组织的温度，这是我们称为“ Hyperablation”的过程。在初步工作中，我们证明，将目标组织的预处理温度提高100C，导致体积消融尺寸增加了60％。其他人已经显示出栓塞或其他方法的好处，可以在消融过程之前减少血流中的对流冷却。拟议的超启动设备将提供一种独特的方法来实现这两种策略，并应导致热消融效率显着提高。该技术的应用可能超出消融，并在许多正在研究的高温（例如热激活的脂质体化疗，区域化疗和高温增强辐射程序）中被证明是有用的。我们将寻求临床合作者的意见，并进行建模模拟，以指导高温导管的设计。我们将使用生理条件和组织样品在台式设置中进行材料，制造原型，并在台式设置中测试设备。最后，我们将与介入放射学专家合作，在大型动物模型中测试该装置，并在肝脏热消融中评估这种治疗方法的性能和潜在益处。在该项目结束时，我们将确定使用该设备创建本地热疗的可行性，并了解这种方法的潜在好处和应用。公共卫生相关性：I阶段I SBIR赠款提案的目标是开发一种新型导管技术，能够在消融程序之前诱导当地的高温和停止血液流动。该系统将有助于增强消融区的大小，并可能通过其他化学疗法和辐射方案找到应用。该建议的重点是台式和试点动物研究中原型设备的设计，制造和测试