Local Hyperthermia Catheter for Enhanced Ablation and Cancer Therapy

用于增强消融和癌症治疗的局部热疗导管

• 批准号: 7908551
• 负责人: Ashok Gowda
• 金额: $ 15.11万
• 依托单位: BIOTEX, INC.
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-01 至 2012-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7908551
• 关键词: Ablation; Animal Model; Animals; Antineoplastic Agents; Applications Grants; Area; Benign; Blood; Blood Cells; Blood Vessels; Blood flow; Cancerous; Catheters; Clinic; Clinical; Clinical Trials; Deposition; Development; Devices; Encapsulated; Engineering; Family suidae; Fever; Goals; Heating; Human; Interventional radiology; Kidney; Lasers; Lead; Liposomes; Liver; Local Hyperthermia; Methodology; Methods; Modeling; Normal tissue morphology; Organ; Organ Temperatures; Performance; Pharmaceutical Preparations; Phase; Physiological; Pilot Projects; Procedures; Process; Protocols documentation; Radiation; Radiofrequency Interstitial Ablation; Regional Chemotherapy; Research; Rest; Small Business Innovation Research Grant; Solid Neoplasm; Solutions; Source; Specialist; Structure; System; Technology; Temperature; Testing; Therapeutic Embolization; Thermal Ablation Therapy; Time; Tissue Sample; Tissues; To specify; Work; base; cancer therapy; chemotherapy; design; dosimetry; improved; interstitial; minimally invasive; models and simulation; novel; operation; prototype; public health relevance; radiologist; tumor

DESCRIPTION (provided by applicant): The goal of this Phase I SBIR Grant Proposal is to develop a new device and methodology for local elevation of a target tissue's temperature prior to a planned thermal ablation, a process we've dubbed "hyperablation". In preliminary work we demonstrated that raising the pre-treated temperature of a target tissue by 100C resulted in a 60% increase in volumetric ablation size. Others have shown the benefits of embolization or other methods to decrease convective cooling from blood flow prior to an ablation procedure. The proposed hyperablation device would provide a unique way to accomplish both strategies and should lead to a significant increase in thermal ablation efficiency. Application of this technology may go beyond ablation and prove useful in a number of areas where hyperthermia is being investigated such as heat- activated liposomal chemotherapy, regional chemotherapy, and hyperthermia-enhanced radiation procedures. We will seek input from clinical collaborators and perform modeling simulations to guide the design of the hyperthermia catheter. We will source materials, fabricate prototypes, and test the device in a benchtop setup using physiologic conditions and tissue samples. Finally, we will work with clinical experts in interventional radiology to test the device in a large animal model and evaluate the performance and potential benefits of this treatment approach in the context of thermal ablation in the liver. At the end of this project, we will have determined the feasibility of creating local hyperthermia with this device and understand the potential benefits and applications for this approach. PUBLIC HEALTH RELEVANCE: The goal of this Phase I SBIR Grant proposal is to develop a novel catheter technology capable of inducing local hyperthermia and halting blood flow prior to an ablation procedure. The system will be useful for enhancing ablation zone size and may find application with other chemotherapy and radiation based protocols. This proposal is focused on design, fabrication, and testing of a prototype device in benchtop and pilot animal studies

描述(由申请人提供)：这项第一阶段SBIR资助提案的目标是开发一种新的设备和方法，用于在计划中的热消融之前局部提高目标组织的温度，我们将这一过程称为“超消融”。在初步工作中，我们证明了将靶组织的前处理温度提高100摄氏度会导致体积消融大小增加60%。其他人则显示了栓塞术或其他方法在消融手术前减少血流对流冷却的好处。拟议的超消融装置将为实现这两种策略提供一种独特的方式，并应导致热消融效率的显着提高。这项技术的应用可能超越消融，并在许多正在研究热疗的领域被证明是有用的，如热激活脂质体化疗、区域化疗和热疗增强放射治疗。我们将寻求临床合作者的意见，并进行建模模拟，以指导热疗导管的设计。我们将寻找材料，制造原型，并在台式设备上使用生理条件和组织样本测试设备。最后，我们将与介入放射学的临床专家合作，在大型动物模型中测试该设备，并在肝脏热消融的背景下评估这种治疗方法的性能和潜在好处。在这个项目结束时，我们将确定使用该设备创建局部热疗的可行性，并了解这种方法的潜在好处和应用。 公共卫生相关性：这项第一阶段SBIR赠款提案的目标是开发一种新的导管技术，能够在消融程序之前诱导局部体温升高和停止血流。该系统将有助于扩大消融区的大小，并可能在其他基于化疗和放射的方案中得到应用。该方案的重点是在台式和先导性动物实验中设计、制造和测试原型装置。