Depth Maps From Stereo Images Of The Optic Disc

视盘立体图像的深度图

• 批准号: 6484469
• 负责人: MARK P WILSON
• 金额: $ 10万
• 依托单位: KESTREL CORPORATION
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-06-01 至 2002-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6484469
• 关键词: bioimaging /biomedical imaging; biomedical equipment development; clinical research; computer program /software; computer system design /evaluation; diagnosis design /evaluation; digital imaging; early diagnosis; glaucoma; glaucoma test; human data; image processing; neuroanatomy; optic disk; optic nerve; stereophotography

DESCRIPTION (provided by applicant): Glaucoma is a chronic disease whose causes are not well understood. It is estimated that three million Americans have glaucoma, and 67 million people worldwide will have glaucoma by the year 2000. At least half do not know they have it because glaucoma usually has no symptoms in the early stages. Untreated, glaucoma is a leading cause of irreversible blindness. An important goal of current research is to develop methods of early diagnosis to detect the disease in the early stages, when treatment is most effective in minimizing irreversible vision loss. Currently, the identification of early pathologic changes at the optic nerve head (ONH) is crucial to the diagnosis of glaucoma. The current gold standard for measuring these changes is through clinical stereoscopic observation of the ONH. From the American Academy of Ophthology (AAO) 2000, "Previous studies have found that the diagnostic precision of qualitative evaluation of stereoscopic ONH photographs by experienced clinical observers is superior to any other currently available method of optic disc assessment." (Identifying Early Glaucomatous Changes, Wollstein, Health, 2000 AAO). The major drawback to the stereoscopic evaluation is the subjectivity which creating inter and intra-observer reader variability. A new method for evaluation to stereoscopic photographs is needed for consistent analysis of the changes on the optic nerve head. This can be brought about by the use quantitative analysis of the ONH changes. The phase I project will be used to improve a technique for calculating disparity maps based on a pair of stereoscopic images. This technique has already proven to give good results, though it needs to be tuned for this specific application. Once the topography is found, basic image processing algorithms can be used to locate the disc and cup boundaries and calculate the volume of the cup. The algorithm will be compared to several pre-diagnosed cases for testing the accuracy. This will lead to the Phase II project, which will use digitized stereoscopic image of the optic nerve head for longitudinal measurements. These measurements will include three-dimensional changes in the dimensions of the cup and disk over a period of time. The measurements will be calculated on pre-diagnosed images for comparison with and expert reader. Collaborators from the University of Iowa and the University of Texas Medical Center in San Antonio will provide these analyses.

描述（由申请人提供）：青光眼是一种慢性疾病， 并没有得到很好的理解。据估计，有300万美国人 青光眼，到2000年全世界将有6700万人患有青光眼。 至少有一半的人不知道他们患有青光眼，因为青光眼通常没有症状 在早期阶段。如果不治疗，青光眼是导致不可逆性青光眼的主要原因。 失明目前研究的一个重要目标是开发早期诊断的方法。 诊断，以发现疾病的早期阶段，当治疗是最 有效减少不可逆的视力丧失。目前，鉴定 视神经乳头（ONH）的早期病理变化对于 青光眼的诊断目前衡量这些变化的黄金标准是 通过对ONH的临床立体观察。来自美国科学院 Ophthology（AAO）2000，“以前的研究发现， 立体ONH照片定性评价的精确度， 经验丰富的临床观察员优于任何其他目前可用的上级 视盘评估方法。“（识别早期青光眼变化， Wollstein，Health，2000 AAO）。 立体评价的主要缺点是主观性， 产生观察者之间和观察者内部的阅读者可变性。的新方法 评价立体照片是必要的一致性分析， 视神经头的变化这可以通过使用 定量分析ONH的变化。一期工程将用于 改进用于基于一对 立体图像。这项技术已经证明能产生良好的效果， 尽管它需要针对该特定应用进行调整。一旦地形 基本的图像处理算法可用于定位盘， 杯子边界并计算杯子的体积。算法将是 与几个预先诊断的病例进行比较，以测试准确性。这将 导致第二阶段的项目，这将使用数字化立体图像的 用于纵向测量的视神经乳头。这些测量将 包括杯和盘的尺寸的三维变化 段时间将在预诊断图像上计算测量值， 与专家读者进行比较。来自爱荷华州大学的合作者 圣安东尼奥的德克萨斯大学医学中心将提供这些 分析。

项目成果

Digital stereo image analyzer for generating automated 3-D measures of optic disc deformation in glaucoma.

数字立体图像分析仪，用于生成青光眼视盘变形的自动 3D 测量结果。

• DOI: 10.1109/tmi.2002.806293
• 发表时间: 2002
• 期刊: IEEE transactions on medical imaging.
• 作者: Corona,Enrique;Mitra,Sunanda;Wilson,Mark;Krile,Thomas;Kwon,YoungH;Soliz,Peter
• 通讯作者: Soliz,Peter