Novel Enzymatic Reductive Amination
Novel Enzymatic Reductive Amination
批准号:
6481774
负责人:
JAMES DAVID ROZZELL
金额:
$11.46万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2002
资助国家:
美国
项目状态:
已结题
起止时间:
2002-05-01 至 2002-12-31
中文摘要
描述(申请人提供):手性胺是一类重要的
英文摘要
DESCRIPTION (provided by applicant): Chiral amines are an important class of
pharmaceutical intermediates. In Phase 1 we propose to use directed evolution
methods to create the first group of amine dehydrogenase enzymes evolved to
catalyze the stereoselective reductive amination of ketones to the
corresponding chiral amines. A patent-pending assay for use in high throughput
screening has already been developed and validated for the detection of new
amino acid dehydrogenase activities, and we will adapt this method to establish
a high throughput screen for detecting new "amine dehydrogenases." These new
enzymes will then be characterized and evaluated for the production of chiral
amines by the reductive amination of ketones. In contrast to resolution
methods, the reductive amination process is a chiral synthesis, and up to 100
percent of the starting material can be converted into the enantiomerically
pure product in a single step using readily available, inexpensive ketone
starting materials. Success in Phase 1 will lay the foundation for an expanded
development of amine dehydrogenases capable of catalyzing the production of a
wide range of chiral amines in Phase 2.
PROPOSED COMMERCIAL APPLICATION: Chiral amines produced using the technology developed have applications as key intermediates for the synthesis of a wide range of pharmaceutically active compounds.
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会议论文
Optimizing Escherichia Coli for Carbonyl reduction
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批准号:6788947
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项目类别:
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资助金额:$10.0万
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财政年份:2004
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负责人:JAMES DAVID ROZZELL
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依托单位:
Evolving Inproved Formate Dehydrogenases
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批准号:6942735
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项目类别:
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资助金额:$37.5万
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财政年份:2003
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负责人:JAMES DAVID ROZZELL
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依托单位:
Evolving Inproved Formate Dehydrogenases
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批准号:6832896
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项目类别:
-
资助金额:$37.5万
-
财政年份:2003
-
负责人:JAMES DAVID ROZZELL
-
依托单位:
Optimizing Escherichia coli for Carbonyl Reductions
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批准号:7185817
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项目类别:
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资助金额:$42.68万
-
财政年份:2001
-
负责人:JAMES DAVID ROZZELL
-
依托单位:
Optimizing Escherichia coli for Carbonyl Reductions
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批准号:7050673
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项目类别:
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资助金额:$41.88万
-
财政年份:2001
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负责人:JAMES DAVID ROZZELL
-
依托单位:
PRODUCTION OF CHIRAL AMINOALCHOLS
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批准号:6070479
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项目类别:
-
资助金额:$14.2万
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财政年份:2000
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负责人:JAMES DAVID ROZZELL
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依托单位:
PRODUCTION OF NON-NATURALLY OCCURRING AMINO ACIDS
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批准号:6374135
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项目类别:
-
资助金额:$29.74万
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财政年份:2000
-
负责人:JAMES DAVID ROZZELL
-
依托单位:
PRODUCTION OF NON-NATURALLY OCCURRING AMINO ACIDS
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批准号:6139964
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项目类别:
-
资助金额:$35.13万
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财政年份:2000
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负责人:JAMES DAVID ROZZELL
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依托单位:
Production of Chiral Aminoalcohols
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批准号:6526061
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项目类别:
-
资助金额:$41.24万
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财政年份:2000
-
负责人:JAMES DAVID ROZZELL
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依托单位:
Production of Chiral Aminoalcohols
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批准号:6401842
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项目类别:
-
资助金额:$50.02万
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财政年份:2000
-
负责人:JAMES DAVID ROZZELL
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依托单位:
METHOD FOR NEONATAL SCREENING FOR HOMOCYSTINURIA
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批准号:6498157
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项目类别:
-
资助金额:$33.04万
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财政年份:1999
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负责人:JAMES DAVID ROZZELL
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依托单位:
SALT-ACTIVATED ENZYMES FOR ORGANIC SYNTHESIS
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批准号:2868077
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项目类别:
-
资助金额:$10.0万
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财政年份:1999
-
负责人:JAMES DAVID ROZZELL
-
依托单位:
PRODUCTION OF NON NATURALLY OCCURRING AMINO ACIDS
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批准号:2867469
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项目类别:
-
资助金额:$10.0万
-
财政年份:1999
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负责人:JAMES DAVID ROZZELL
-
依托单位:
METHOD FOR NEONATAL SCREENING FOR HOMOCYSTINURIA
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批准号:6298893
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项目类别:
-
资助金额:$39.05万
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财政年份:1999
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负责人:JAMES DAVID ROZZELL
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依托单位:
METHOD FOR NEONATAL SCREENING FOR HOMOCYSTINURIA
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批准号:2869526
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项目类别:
-
资助金额:$10.0万
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财政年份:1999
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负责人:JAMES DAVID ROZZELL
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依托单位:
INCORPORATING NEW BASE PAIRS INTO NUCLEIC ACID ANALOGS
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批准号:2024032
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项目类别:
-
资助金额:$10.0万
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财政年份:1997
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负责人:JAMES DAVID ROZZELL
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依托单位: