Cell-Based High Throughput Screening for Anti-Androgens

基于细胞的抗雄激素高通量筛选

基本信息

  • 批准号:
    6484915
  • 负责人:
  • 金额:
    $ 10万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2002
  • 资助国家:
    美国
  • 起止时间:
    2002-04-01 至 2002-09-30
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by the applicant): Prostate cancer is the most frequently diagnosed cancer in American men and the second leading cause of male cancer death. Antiandrogens have been used with castration to prevent the progression of prostate cancer. However, cancer relapse often occurs within 2-3 years in patients who received this therapy. This has prompted interest in developing better antiandrogens for prostate cancer treatment. Traditional Chinese Herbal Medicines (TCHM) have been shown to block recurrent prostate cancer growth. In our preliminary study, using a newly-developed androgen receptor (AR) and androgen receptor co-activator (ARA)-mediated transactivation assay, it was found that some extracts from TCHM inhibited AR-induced gene activation, suggesting TCHM is an excellent source to search for new antiandrogen drugs. A cell-based androgen/AR activation assay developed from this study is advantageous in discovering antiandrogens that exert their inhibitory function at different stages of an androgen-induced gene activation. Performing this assay could lead to the discovery of potentially new and different antiandrogen drugs. Conventional antiandrogens only interfere with androgen and AR binding, such as HF (hydroxyflutamide) or casodex (bicalutamide). In this application we propose to develop a high throughput 96-well format AR/ARA transactivation assay using three prostate cancer cell lines: DU145, PC3 and LNCaP. In collaboration with our corporate partner, Plantaceutica Inc. (Chapel Hill, NC), a large number of extracts and compounds from TCHM that are known to possess ingredients with potential antiandrogen and androgenic activities will be screened. Compounds from TCHM extracts with effects to block wild type AR and mutant AR transactivation in all three human prostate cancer cell models will be further tested in a proliferation assay using androgen-sensitive prostate cancer, LNCaP cells to assess their biological efficacy in suppressing prostate cancer cell growth. Compounds discovered by our study with antiandrogenic or androgenic activities will have great potential to be developed into new drugs that will improve the treatment of prostate cancer patients and other androgen related disorders. PROPOSED COMMERCIAL APPLICATION: NOT AVAILABLE
描述(申请人提供):前列腺癌是最常见的

项目成果

期刊论文数量(0)
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CHARLES C-Y SHIH其他文献

CHARLES C-Y SHIH的其他文献

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{{ truncateString('CHARLES C-Y SHIH', 18)}}的其他基金

Development of an Oral Therapeutic Drug for Spinal and Bulbar Muscular Atrophy
脊髓和延髓肌萎缩症口服治疗药物的开发
  • 批准号:
    8252177
  • 财政年份:
    2011
  • 资助金额:
    $ 10万
  • 项目类别:
Development of an Oral Therapeutic Drug for Spinal and Bulbar Muscular Atrophy
脊髓和延髓肌萎缩症口服治疗药物的开发
  • 批准号:
    8041399
  • 财政年份:
    2011
  • 资助金额:
    $ 10万
  • 项目类别:
Development of an Oral Therapeutic Drug for Spinal and Bulbar Muscular Atrophy
脊髓和延髓肌萎缩症口服治疗药物的开发
  • 批准号:
    8723309
  • 财政年份:
    2011
  • 资助金额:
    $ 10万
  • 项目类别:
A New Topical Antiandrogen Benefits Acne Treatment
一种新的外用抗雄激素有益于痤疮治疗
  • 批准号:
    7274871
  • 财政年份:
    2004
  • 资助金额:
    $ 10万
  • 项目类别:
A New Topical Antiandrogen Benefits Acne Treatment
一种新的外用抗雄激素有益于痤疮治疗
  • 批准号:
    6831937
  • 财政年份:
    2004
  • 资助金额:
    $ 10万
  • 项目类别:
A New Topical Antiandrogen Benefits Acne Treatment
一种新的外用抗雄激素有益于痤疮治疗
  • 批准号:
    7155625
  • 财政年份:
    2004
  • 资助金额:
    $ 10万
  • 项目类别:
Anti-androgenic mechanism of a new compound
新化合物的抗雄激素机制
  • 批准号:
    6550419
  • 财政年份:
    2002
  • 资助金额:
    $ 10万
  • 项目类别:
ANTI-ANDROGEN RECEPTOR MABS FOR HUMAN PROSTATE CANCER
用于人类前列腺癌的抗雄激素受体 MABS
  • 批准号:
    3493269
  • 财政年份:
    1993
  • 资助金额:
    $ 10万
  • 项目类别:

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ONCT-505(一种雄激素受体拮抗剂和降解剂)的临床前开发,作为肯尼迪病的新潜在治疗方法
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  • 财政年份:
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增殖细胞核抗原对去势抵抗性前列腺癌细胞雄激素受体信号传导的调节
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Effects of androgen receptor (AR) signaling on CD4+ T cell metabolism during airway inflammation
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TITLE: BLADDER CANCER CHEMOPREVENTION USING THE ANDROGEN RECEPTOR INHIBITOR APALUTAMIDE
标题:使用雄激素受体抑制剂阿帕鲁胺进行膀胱癌化学预防
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