Deracemization of Amino Acids
Deracemization of Amino Acids
批准号:
6439310
负责人:
SCOTT J NOVICK
金额:
$10.0万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2002
资助国家:
美国
项目状态:
已结题
起止时间:
2002-02-01 至 2002-07-31
中文摘要
点击翻译按钮获取中文摘要
英文摘要
DESCRIPTION (provided by applicant): Unnatural amino acids (UAAs) are growing
in importance as pharmaceutical intermediates, with applications in a number of
current and future drugs. Since UAAs are most always required as pure
stereoisomers, a chiral synthesis is preferred over the resolution methods that
are most commonly employed. In this proposal a one-pot deracemization process
will be developed to prepare pure stereoisomers of UAAs from the readily
available and inexpensive racemic mixtures. Deracemization will be accomplished
by selectively oxidizing the D-amino acid in a D,L-mixture to the corresponding
2-ketoacid, using D-amino acid oxidase, and converting the 2-ketoacid to the
L-amino acid using a stereoselective enzyme-catalyzed reaction. Yields are
expected to approach 100 percent, affording almost complete conversion of the
racemic starting materials to the optically-pure L-UAA. Importantly, the method
coverts the racemic amino acid directly to L-form in a single reaction step
without the need for protecting groups or derivitization. Further, this method
has broad scope, and will be applicable to a wide range of UAA products. Two
alternative coupled enzymatic systems will be studied, and the results compared
to select the biocatalytic method. The method will be demonstrated by producing
gram quantities of four current commercial targets.
PROPOSED COMMERCIAL APPLICATIONS:
Intermediates for the production of pharmaceuticals spanning a wide mage of therapeutic indications.
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批准号:6880705
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项目类别:
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资助金额:$10.0万
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财政年份:2006
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负责人:SCOTT J NOVICK
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依托单位:
One-Step Synthesis of D-Amino Acids
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批准号:6832095
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项目类别:
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资助金额:$10.0万
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财政年份:2004
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负责人:SCOTT J NOVICK
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依托单位:
Deracemization of Amino Acids
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批准号:6709350
-
项目类别:
-
资助金额:$38.63万
-
财政年份:2002
-
负责人:SCOTT J NOVICK
-
依托单位:
Deracemization of Amino Acids
-
批准号:6641951
-
项目类别:
-
资助金额:$45.23万
-
财政年份:2002
-
负责人:SCOTT J NOVICK
-
依托单位:
海外基金