Microfluidic Engineering of Alginate Nanogels for the Delivery of Gene Therapies to the Central Nervous System

海藻酸盐纳米凝胶的微流体工程用于将基因治疗传递到中枢神经系统

• 批准号: 2104164
• 金额: --
• 依托单位: University College London
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2018
• 资助国家: 英国
• 起止时间: 2018 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2104164
• 关键词: Microfluidic; Engineering; Alginate; Nanogels; Delivery

Project Summary While gene therapy is usually performed using viral vectors, non-viral systems may also be used although they are often less effective in delivering expression for the required time period. Our recent work has indicated nanogels may be applicable for the delivery of genetic materials, particularly to the CNS where we have shown suitable expression timeframes. The project will involve the development of microfluidic approaches to develop nanogels as delivery systems for gene therapy. These systems will be used to explore the manufacture, scale up and efficacy of the delivery systems, hence the project activities will range from engineering through to drug delivery and biological assessment. The project will suit a candidate who has a background in drug delivery, engineering and processing and an understanding of the principles and requirements of gene therapy.Main Methods and Techniques to be employedDesign and characterisation of drug delivery systems, microfluidic approaches, biological assessment of the gene expression.

虽然基因治疗通常使用病毒载体进行，但也可以使用非病毒系统，尽管它们在所需的时间段内传递表达的效果往往较差。我们最近的工作表明，纳米凝胶可能适用于遗传物质的传递，特别是到中枢神经系统，我们已经显示出合适的表达时间框架。该项目将涉及微流体方法的开发，以开发纳米凝胶作为基因治疗的递送系统。这些系统将用于探索运载系统的制造、扩大规模和功效，因此项目活动将从工程设计到药物运载和生物评估。该项目将适合候选人谁在药物输送，工程和处理的原则和基因治疗的要求的理解的背景。主要方法和技术要employedDesign和药物输送系统的特性，微流控方法，基因表达的生物学评估。