CORE--SHARED SCIENTIFIC RESOURCES

共享科学资源核心成立于南卡罗来纳医科大学酒精研究中心，旨在促进酒精治疗研究的执行，提高研究效率，最大限度地利用资源，并通过标准化和集中化的服务提供质量控制。所提供的核心服务是为几个项目最有可能使用的服务以及最容易集中的服务量身定做的。在实现最初的具体目标方面取得的进展是突出的。在最初的几年中，雇用和培训了个人，建立了关键系统，并改进了服务组织。由此产生的系统运行顺利，核心服务被许多由中心拨款内外资助的酒精研究人员使用，对服务的需求继续增长。通过鼓励各项目合作，加强了沟通，建立了一个有凝聚力的工作单位，提高了数据库管理效率，提高了生产率。这份续签申请建议延续原有的三个具体目标，并增加一个新的目标。持续的具体目标是：1)继续提供集中的主观招聘和筛选；2)继续提供集中的药学、医疗和实验室服务；以及3)继续提供统计和数据库管理服务。新的目标，具体目标4，是发展和提供集中研究助理培训。后一项目标代表着我们集中职能的自然延伸，预计将导致各项研究更加一致，并加强科学质量控制。总而言之，服务的集中化明显提高了任何大型研究活动的质量和效率，但重要的是，它减少了重复劳动和对可用资源的竞争，特别是对主题的竞争。随后是建立一个明确界定的共享科学资源核心的初始资助期。领导力很强，获得服务的途径已经明确，质量控制得到持续监测。

The Shared Scientific Resource Core was established in the Alcohol Research Center at the Medical University of South Carolina to facilitate the execution of alcohol treatment research, to improve research efficiency, to maximize resource utilization, and to provide quality control through standardization and centralization of services. The Core services provided were tailored to those most likely to be utilized by several projects as well as those most amenable to centralization. The progress made in addressing the original specific aims were outstanding. Individuals were hired and trained, critical systems were put into place, and services organization were refined over the course of the first few years. The resulting systems function smoothly, the Core services are utilized by many alcohol researchers funded both inside and outside of the Center grant, and demand for services continues to grow. By encouraging the various projects to work together, communication has been enhanced, a cohesive working unit has been established, database management has been efficient, and productivity has been increased. This renewal application proposes to continue three of the original specific aims and to add one new aim. The continuing Specific Aims are: 1) to continue to provide centralized subjective recruitment and screening; 2) to continue to provide centralized pharmacy, medical, and laboratory services; and 3) to continue to provide statistical and database management services. The new aim, Specific Aim 4, is to develop and provide centralized research assistant training. This latter aim represents a natural extension of our centralized functions and is expected to result in more uniformity across studies and enhanced scientific quality control. In summary, centralization of services clearly improves quality and efficiency in any large research operation, but importantly it reduces duplication of effort and competition for available resources, especially subjects. The initial funding period followed for the establishment of a well-defined Shared Scientific Resource Core. Leadership is strong, the access to the services has been clearly identified, and quality control is continuously monitored.