COOPERATIVE BREAST CANCER TISSUE REGISTRY

描述：(申请人描述) 国家癌症研究所(NCI)创建了一个多机构 合作乳腺癌组织资源(CBCTR)作为一种采购手段 并分发存档的石蜡包埋乳腺癌组织 已知临床结果的患者支持调查人员验证 潜在的预后和治疗标志物。到目前为止，该资源具有 对8,805名乳腺癌患者的数据和组织进行了分类。这 与之竞争的延续应用描述了为 CBCTR自1993年开始提供资金以来。这包括核心人员， 计算机化的中央和本地数据库以及组织储存库。这 申请描述了注册组织是如何分类的； 选择、存储和检索相关组织；协调 临床数据和组织；以及研究人员获得 对资源的访问权限。组织是如何准备和分配到 研究人员，以及已经被 还概述了为实现资源目标而开发的资源。人类 与过量使用有关的主题、指南和法医学方面 用于研究的组织被提及。迈阿密大学杰克逊纪念馆 医院是NCI发起的这个合作社的重要组成部分 提供资源，并承诺全力合作，继续帮助实现其目标。

DESCRIPTION: (Applicant's Description) The National Cancer Institute (NCI) has created a multi-institutional Cooperative Breast Cancer Tissue Resource (CBCTR) as a means of procuring and distributing archived paraffin embedded breast cancer tissues from patients with a known clinical outcome to support investigators validating potential prognostic and therapeutic markers. To date, this resource has catalogued data and tissues from 8,805 breast cancer patients. This competing continuation application describes the infrastructure created for the CBCTR since funding began in 1993. This includes the core personnel, computerized central and local databases, and tissue repositories. This application describes how registered tissues were categorized; the means of selecting, storing, and retrieving pertinent tissues; the coordination of clinical data and tissues; and the mechanism by which investigators gain access to the resource. How the tissues are prepared and distributed to researchers, as well as the quality control procedures that have been developed to achieve the goals of the resource are also outlined. The human subjects guidelines and medicolegal aspects bearing on the use of excess tissue for research are addressed. The University of Miami Jackson Memorial Hospital is an important component of this NCI-sponsored Cooperative Resource and pledges full cooperation to continue to help achieve its goals.