COOPERATIVE BREAST CANCER TISSUE REGISTRY

描述：（申请人的描述） 国家癌症研究所（NCI）创建了一个多机构 合作乳腺癌组织资源（CBCTR）作为采购的一种手段， 并分发存档的石蜡包埋的乳腺癌组织， 具有已知临床结局的患者，以支持研究者验证 潜在的预后和治疗标志物。 到目前为止，该资源 收集了8,805名乳腺癌患者的数据和组织 这 竞争延续应用程序描述了为 CBCTR自1993年开始资助以来。 这包括核心人员， 计算机化的中央和地方数据库以及组织储存库。 这 申请描述了注册组织的分类方式; 选择、储存和检索相关组织; 临床数据和组织;以及研究者获得 访问资源。 如何制备组织并将其分发至 研究人员，以及质量控制程序， 还概述了为实现资源目标而开发的资源。 人类 与过量使用有关的主题、指南和法医学方面 组织研究的解决。 迈阿密大学杰克逊纪念馆 医院是这个NCI赞助的合作社的重要组成部分 资源，并保证充分合作，继续帮助实现其目标。

DESCRIPTION: (Applicant's Description) The National Cancer Institute (NCI) has created a multi-institutional Cooperative Breast Cancer Tissue Resource (CBCTR) as a means of procuring and distributing archived paraffin embedded breast cancer tissues from patients with a known clinical outcome to support investigators validating potential prognostic and therapeutic markers. To date, this resource has catalogued data and tissues from 8,805 breast cancer patients. This competing continuation application describes the infrastructure created for the CBCTR since funding began in 1993. This includes the core personnel, computerized central and local databases, and tissue repositories. This application describes how registered tissues were categorized; the means of selecting, storing, and retrieving pertinent tissues; the coordination of clinical data and tissues; and the mechanism by which investigators gain access to the resource. How the tissues are prepared and distributed to researchers, as well as the quality control procedures that have been developed to achieve the goals of the resource are also outlined. The human subjects guidelines and medicolegal aspects bearing on the use of excess tissue for research are addressed. The University of Miami Jackson Memorial Hospital is an important component of this NCI-sponsored Cooperative Resource and pledges full cooperation to continue to help achieve its goals.