CORE--NUCLEAR MAGNETIC RESONANCE

描述：（申请人的描述）核磁共振（NMR） Core提供最先进的NMR仪器， 科罗拉多大学综合癌症中心的成员。NMR 光谱学用于研究生物的结构和动力学 原子分辨率的大分子。这些信息对于 了解癌蛋白，肿瘤抑制因子， 信号蛋白和其他与发育有关的分子， 癌症的进展和检测。此外，NMR数据越来越多地 对于基于结构的设计和治疗剂的筛选是重要的 用于治疗癌症NMR应用方面的专业知识 光谱学提供给癌症中心的成员，以解决结构 以及其他结构生物学技术 包括分子结构的三维可视化， 培训、服务、咨询和协作。

Description: (Applicant's Description) The Nuclear Magnetic Resonance (NMR) Core provides access to state-of-the-art NMR instrumentation for use by members of the University of Colorado Comprehensive Cancer Center. NMR Spectroscopy is used to study the structures and dynamics of biological macromolecules at atomic resolution. This information is vital to understanding the molecular mechanisms of oncoproteins, tumor suppressors, signaling proteins, and other molecules implicated in the development, progression and detection of cancer. In addition, NMR data is increasingly important for the structure-based design and screening of therapeutic agents developed for the treatment of cancer. Expertise in the application of NMR spectroscopy is provided to members of the Cancer Center to solve structures of important molecules and also in other structural biology techniques including three-dimensional visualization of molecular structures through training, service, consultation, and collaboration.