CELL BIOLOGY

描述：（申请人的描述）细胞的科学目标 生物学课程是1）了解细胞增殖的机制， 细胞死亡和癌症发展、进展、侵袭和转移， （2）在此基础上制定癌症干预策略。 该计划致力于通过以下方式加强对这项研究的基础设施支持： 通过招聘，提供研讨会、核心支持和指导， 以及促进研究合作。细胞生物学计划 统一的研究主题包括涉及的监管机制， 增殖和凋亡，膜运输和受体再循环，细胞 表面相互作用和运动，以及它们在癌症中的应用。有 三个部分重叠的重点领域："增殖和凋亡"， "宿主-肿瘤相互作用"和"膜运输。"该计划包括一个 杰出的信号组与两个HHMI调查员和吉米五获奖者， 它已经产生了许多内部和跨程序的合作， 有几家联合持有研究补助金。该计划的29个成员国约有 750万美元的年度直接费用赠款支持。其中包括14个项目 由NCI和其他癌症（同行评审）机构资助， 每年90万美元的直接支持，以及几个计划项目， 其他多成员赠款。该方案的活动包括建立 一个新的研讨会系列，跨学科的组织基础-临床 最小对称，授予试点和博士后发展奖， 参与核心开发（蛋白质分析、质谱分析和 细胞成像），并在细胞成像领域招聘一名新的教员 粘附/运动/转移。

Description: (Applicant's Description) The scientific goals of the Cell Biology Program are 1) to understand the mechanisms of cell proliferation and cell death and of cancer development, progression, invasion and metastasis, and 2) to develop cancer intervention strategies based on this understanding. The Program endeavors to enhance infrastructure support for this research by providing seminars, core support and mentoring, by conducting recruitments, and by facilitating research collaborations. The Cell Biology Program's unifying research theme comprises the regulatory mechanisms involved in proliferation and apoptosis, membrane traffic and receptor recycling, cell surface interactions and motility, and their applications to cancer. There are three partially overlapping focus areas: "Proliferation and Apoptosis," "Host-Tumor Interactions," and "Membrane Traffic." The Program includes an outstanding signaling group with two HHMI investigators and a Jimmy V awardee, and it has generated numerous intra- and inter-program collaborations and several jointly held research grants. The 29 members of the Program have about $7.5 million in annual direct cost grant support. This includes 14 projects funded by the NCI and other cancer (peer-reviewed) agencies totaling over $900,000 in annual direct support, as well as several program project and other multi-member grants. The Program's activities include the establishment of a new seminar series, the organization of interdisciplinary basic-clinical minisymposia, the granting of pilot and postdoctoral development awards, the participation in core development (protein analysis, mass spectrometry, and cell imaging), and the recruitment of a new faculty member in the area of cell adhesion/motility/metastasis.