CELL BIOLOGY

细胞生物学

• 批准号: 6589978
• 负责人: KARL H PFENNINGER
• 金额: $ 25.04万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-05-06 至 2003-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6589978
• 关键词: apoptosis; carcinogenesis; cell adhesion; cell biology; cell death; cell motility; cell proliferation; mass spectrometry; metastasis; neoplasm /cancer; neoplasm /cancer invasiveness; receptor binding

Description: (Applicant's Description) The scientific goals of the Cell Biology Program are 1) to understand the mechanisms of cell proliferation and cell death and of cancer development, progression, invasion and metastasis, and 2) to develop cancer intervention strategies based on this understanding. The Program endeavors to enhance infrastructure support for this research by providing seminars, core support and mentoring, by conducting recruitments, and by facilitating research collaborations. The Cell Biology Program's unifying research theme comprises the regulatory mechanisms involved in proliferation and apoptosis, membrane traffic and receptor recycling, cell surface interactions and motility, and their applications to cancer. There are three partially overlapping focus areas: "Proliferation and Apoptosis," "Host-Tumor Interactions," and "Membrane Traffic." The Program includes an outstanding signaling group with two HHMI investigators and a Jimmy V awardee, and it has generated numerous intra- and inter-program collaborations and several jointly held research grants. The 29 members of the Program have about $7.5 million in annual direct cost grant support. This includes 14 projects funded by the NCI and other cancer (peer-reviewed) agencies totaling over $900,000 in annual direct support, as well as several program project and other multi-member grants. The Program's activities include the establishment of a new seminar series, the organization of interdisciplinary basic-clinical minisymposia, the granting of pilot and postdoctoral development awards, the participation in core development (protein analysis, mass spectrometry, and cell imaging), and the recruitment of a new faculty member in the area of cell adhesion/motility/metastasis.

描述：(申请人的描述)该细胞的科学目标 生物学课程有：1)了解细胞增殖机制和 细胞死亡和癌症的发展、进展、侵袭和转移， 2)在此基础上制定癌症干预策略。 该计划致力于通过以下方式加强对这项研究的基础设施支持 提供研讨会、核心支持和指导，通过进行招聘， 并通过促进研究合作。细胞生物学项目 统一研究主题包括涉及的监管机制 增殖和凋亡、膜运输和受体再循环、细胞 表面相互作用和运动性及其在癌症中的应用。确实有 三个部分重叠的焦点领域：“增殖和凋亡，” “宿主-肿瘤相互作用”和“膜交通”。该计划包括 杰出的信号小组，拥有两名HHMI调查人员和一名吉米·V奖获得者， 它已经产生了许多计划内和计划间的合作， 几个人共同持有研究补助金。该计划的29个成员有大约 每年750万美元的直接成本赠款支持。这包括14个项目 由NCI和其他癌症(同行审查)机构资助，总计超过 90万美元的年度直接支持，以及几个方案项目和 其他多人助学金。该方案的活动包括建立 一个新的系列研讨会，组织跨学科的基础-临床 小型项目，颁发试点和博士后发展奖， 参与核心开发(蛋白质分析、质谱分析和 细胞成像)，并在细胞领域招聘一名新的教员 黏附/运动/转移。