MOLECULAR AND STRUCTURAL BIOLOGY PROGRAM

描述：（申请人的描述）分子和结构生物学 该计划汇集了23名优秀的调查员，代表10个 部门，3 UCHSC学校（医学，药学和研究生院）， 和2个姐妹机构（UCHSC和CU-Boulder）。科学和 该计划的计划目标是阐明关键的基本过程 参与癌症生物学，并扩大分子结构的组成部分， 方案，分别。我们在开发结构化 生物学倡议已经扩大了我们的计划到基础的尖端领域 科学该计划已被重新组织，成员现在分为 三大实力重点：核酸代谢、基因转录 分子结构。这个资金充足的调查小组（6.3美元） 百万美元;直接成本）提供了对分子机制的关键见解 调节：DNA复制、修复和重排; RNA反式剪接 和mRNA加工;阶段特异性、细胞特异性和信号特异性基因转录;和 在阐明DNA、RNA、蛋白质和药物的化学结构方面 分子。在过去的五年里，我们的计划有了显着的增长 在总支持（23%），NCI支持（537%）和其他癌症支持（254%）中， 取得了显著的进步此外，成员们发表了超过 在备受推崇的期刊上发表了200篇报告，强调了国家的突出地位 的计划教师。项目成员通过多种机制进行互动，包括 每月研讨会、年度务虚会、年度区域专题会议和年度 小型研讨会这些正式的互动机制提供了多种 交流信息和开展合作的机会。的 程序大量使用DNA测序、组织培养/单克隆 抗体、蛋白质化学和流式细胞术核心。我们未来的计划是 进一步发展分子结构组，特别是在以下领域： 蛋白质组学，并提供关键的见解的分子机制， DNA复制机制，转录装置， 和RNA加工成分导致癌症。

Description: (Applicant's Description) The Molecular and Structural Biology Program brings together 23 outstanding investigators representing 10 departments, 3 UCHSC Schools (Medicine, Pharmacy, and the Graduate school), and 2 sister institutions (UCHSC & CU-Boulder). The scientific and programmatic goals of the Program are to elucidate key fundamental processes involved in cancer biology and to expand the molecular structure component of the Program, respectively. Our tremendous success in developing a Structural Biology initiative has broadened our Program into cutting-edge areas of basic science. The Program has been re-organized and members are now divided into three focal points of strength: Nucleic Acid Metabolism, Gene Transcription and Molecular Structure. This very well funded group of investigators ($6.3 million; direct costs) has provided key insights into molecular mechanisms regulating: DNA replication, repair, and re-arrangements; RNA trans-splicing and mRNA processing; stage-, cell- and signal-specific gene transcription; and in elucidating the chemical structures of DNA, RNA, protein and drug molecules. During the past five years our Program has had dramatic increases in total support (23%), NCI support (537%), and other Cancer Support (254%), showing remarkable progress. Additionally, members have published more than 200 reports in highly respected journals, underscoring the national prominence of Program faculty. Program members interact via several mechanisms, including monthly seminars, annual retreat, annual regional topical meetings, and annual mini-symposium. These formal mechanisms of interaction provide multiple opportunities for exchange of information and collaborative efforts. The Program makes heavy use of the DNA Sequencing, Tissue Culture/Monoclonal Antibody, Protein Chemistry and Flow Cytometry Cores. Our future plans are to further develop the Molecular Structure group, particularly in the area of proteomics, and to provide critical insights into the molecular mechanisms by which aberrations of the DNA replication machinery, transcription apparatus, and RNA processing components lead to cancer.