Electrochemical Umpolung Arylation of Ketones

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The synthesis of a-arylated carbonyl moieties is important because they are wide-spread throughout bio-active pharmaceuticals, including HIV and non-steroidal anti-inflammatory drugs. Current methods to install this structure require building-blocks with pre-installed functionality, which increases the cost and waste generated. Methods that employ unfunctionalised substrates is an unsolved problem. By exploiting an electrochemical oxidation strategy, we will develop new a-arylation methods that use unfunctionalised substrates, which will be more inexpensive, produce less waste and expand the scope of previous protocols. By increasing the efficiency, availability of suitable substrates and widening the scope of products from this reaction, the chemical space- from which the discovery of drugs rely- can be enhanced. This project is timely, because electrochemical redox processes are becoming increasingly popular in industry and academia as they are highly sustainable and selective.