SALIVA & ANTI CANDIDAL DEFENSE MECHANISMS IN HIV & AIDS

唾液

• 批准号: 6586809
• 负责人: CHIH-KO YEH
• 金额: $ 23.48万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-12-01 至 2002-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6586809
• 关键词: AIDS therapy; HIV infections; candidiasis; clinical research; human subject; human therapy evaluation; longitudinal human study; oral mucosa; pathologic process; saliva; salivary glands; virus infection mechanism

This study is based on the hypotheses that: 1) alterations in salivary gland function are associated with the progression of HIV infection and these alterations predispose to oral candidiasis; 2) with increasing severity of HIV infection, patients develop Sjogren's Syndrome-like features. The study will cross-sectionally and longitudinally determine salivary gland changes at the different stages of HIV infection, it will determine the changes in salivary anti-candidal activities with the progression of HIV infection, and will determine the similarities and differences in salivary gland function of HIV-infected patients in comparison to those with Sjogren's. The study will utilize age- and sex-matched sero-negative controls and patients at different stages of HIV infection.

本研究基于以下假设：1）唾液腺功能的改变与HIV感染的进展相关，这些改变易患口腔念珠菌病; 2）随着HIV感染的严重程度增加，患者出现干燥综合征样特征。 该研究将横向和纵向确定唾液腺在HIV感染的不同阶段的变化，它将确定唾液抗念珠菌活性随着HIV感染的进展而变化，并将确定HIV感染患者与Sjogren患者相比唾液腺功能的相似性和差异。 该研究将使用年龄和性别匹配的血清阴性对照和处于不同HIV感染阶段的患者。