Investigating the immune response to breast cancer stem cell antigens: implications for cancer diagnosis and therapy.

研究对乳腺癌干细胞抗原的免疫反应：对癌症诊断和治疗的影响。

• 批准号: 2106186
• 金额: --
• 依托单位: University of Nottingham
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2018
• 资助国家: 英国
• 起止时间: 2018 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2106186
• 关键词: Investigating; immune; response; breast; cancer

Antibodies against tumour antigens are commonly found in serum of patients and they can be used as powerful diagnostic tool. In our laboratory, we have established that autoantibodies against cancer stem cell antigens can be detected in breast cancer patient sera. This project aims to investigate the detection of autoantibodies in patients affected by triple negative breast cancer (a type of aggressive cancer that affects younger women and for which there is no early detection method and targeted therapy). We aim to identify the antigens at the basis of the immune response that can be used to develop novel diagnostics and effective therapies for this aggressive type of cancer.

抗肿瘤抗原抗体广泛存在于患者血清中，可作为一种强有力的诊断工具。在我们的实验室，我们已经证实在乳腺癌患者血清中可以检测到抗癌干细胞抗原的自身抗体。该项目旨在调查三阴性乳腺癌患者的自身抗体检测情况。三阴性乳腺癌是一种侵袭性癌症，影响年轻女性，目前还没有早期检测方法和有针对性的治疗方法。我们的目标是在免疫反应的基础上识别抗原，这些抗原可用于开发这种侵袭性癌症的新诊断和有效治疗方法。