Environmental regulation of virulence in attaching and effacing enterobacteria

附着和消除肠细菌毒力的环境调节

• 批准号: nhmrc : 566775
• 负责人: Dr Ji Yang
• 金额: $ 37.95万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/environmental-regulation-virulence-effacing-enterobacteria/94761
• 关键词: Environmental; regulation; virulence; attaching; effacing

Disease-causing bacteria must respond to the extreme conditions, such as acid and bile, which they encounter in their hosts. They achieve this by sensing their environment and activating genes that enhance their survival and ability to cause disease. In this project we will define the mechanisms by which these sensing and response pathways occur, using E. coli as a model. The information obtained from this research should lead to new strategies to treat and prevent bacterial infections.

致病细菌必须对它们在宿主体内遇到的极端条件作出反应，如酸和胆汁。它们通过感知环境和激活基因来实现这一点，这些基因增强了它们的生存能力和致病能力。在这个项目中，我们将定义这些传感和反应途径发生的机制，使用E。大肠杆菌作为模型。从这项研究中获得的信息应该会导致治疗和预防细菌感染的新策略。