Environmental adaptation by Vibrio cholerae

霍乱弧菌的环境适应

基本信息

项目摘要

PROJECT SUMMARY/ABSTRACT Cholera is an acute diarrheal disease that affects 3-5 million people each year. Cholera is an is caused by the Gram negative bacterium Vibrio cholerae and is frequently associated with epidemic disease. V. cholerae is a native to aquatic ecosystems and a facultative human pathogen that infects people through the consumption of contaminated water or food. Once ingested, V. cholerae colonizes the small intestine where it produces a toxin that causes a dehydrating secretory diarrhea that can be rapidly fatal. The devastating consequences of cholera, combined with the rapidity with which it can spread and its ability to persist in aquatic ecosystems, underscore the need for the development of novel approaches to combat this epidemic disease. Our recent studies in V. cholerae documented that multiple drug efflux systems belonging to the resistance-nodulation-division (RND) superfamily function to efflux cellular metabolites from the cell. We further showed that impaired efflux resulted in the metabolites accumulating intracellularly where they interacted with periplasmic sensor proteins to initiate adaptive responses. This included the activation of ToxR which resulted in increased leuO transcription and the downregulation of virulence gene expression. However, the metabolites that were responsible for virulence repression remain unknown. In this proposal we will test the hypothesis that auto-inducers function to initiate the expression of the adaptive responses that resulted in virulence repression. Two specific aims are proposed. The first aim will investigate the function of ToxR and LeuO in cell density-dependent gene regulation. The second aim will investigate the contribution of RND-mediated efflux to adaptive responses and colonization. Determining the regulatory mechanisms and environmental cues that modulate V. cholerae adaptive responses will illuminate important aspects of V. cholerae pathogenesis, provide a better understanding of the factors that contribute to disease and epidemic spread, and highlight novel approaches to combat cholera.
项目总结/文摘

项目成果

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JAMES Edward BINA其他文献

JAMES Edward BINA的其他文献

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{{ truncateString('JAMES Edward BINA', 18)}}的其他基金

Function of the Klebsiella pneumoniae RND efflux systems
肺炎克雷伯菌 RND 外排系统的功能
  • 批准号:
    10649576
  • 财政年份:
    2022
  • 资助金额:
    $ 27.92万
  • 项目类别:
Function of the Klebsiella pneumoniae RND efflux systems
肺炎克雷伯菌 RND 外排系统的功能
  • 批准号:
    10525108
  • 财政年份:
    2022
  • 资助金额:
    $ 27.92万
  • 项目类别:
Environmental adaptation by Vibrio cholerae
霍乱弧菌的环境适应
  • 批准号:
    10633541
  • 财政年份:
    2018
  • 资助金额:
    $ 27.92万
  • 项目类别:
Environmental adaptation by Vibrio cholerae
霍乱弧菌的环境适应
  • 批准号:
    9975688
  • 财政年份:
    2018
  • 资助金额:
    $ 27.92万
  • 项目类别:
Environmental adaptation by Vibrio cholerae
霍乱弧菌的环境适应
  • 批准号:
    10228740
  • 财政年份:
    2018
  • 资助金额:
    $ 27.92万
  • 项目类别:
Environmental adaptation by Vibrio cholerae
霍乱弧菌的环境适应
  • 批准号:
    9755358
  • 财政年份:
    2018
  • 资助金额:
    $ 27.92万
  • 项目类别:
Role of cyclo(Phe-Pro) in Vibrio cholerae virulence factor production
环(Phe-Pro)在霍乱弧菌毒力因子产生中的作用
  • 批准号:
    8186812
  • 财政年份:
    2011
  • 资助金额:
    $ 27.92万
  • 项目类别:
Role of cyclo(Phe-Pro) in Vibrio cholerae virulence factor production
环(Phe-Pro)在霍乱弧菌毒力因子产生中的作用
  • 批准号:
    8423427
  • 财政年份:
    2011
  • 资助金额:
    $ 27.92万
  • 项目类别:
Role of cyclo(Phe-Pro) in Vibrio cholerae virulence factor production
环(Phe-Pro)在霍乱弧菌毒力因子产生中的作用
  • 批准号:
    8258229
  • 财政年份:
    2011
  • 资助金额:
    $ 27.92万
  • 项目类别:
Role of cyclo(Phe-Pro) in Vibrio cholerae virulence factor production
环(Phe-Pro)在霍乱弧菌毒力因子产生中的作用
  • 批准号:
    8449172
  • 财政年份:
    2011
  • 资助金额:
    $ 27.92万
  • 项目类别:

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