Simultaneous Emission and Transmission Mammotomography

同时发射和透射乳腺断层扫描

• 批准号: 6659816
• 负责人: MARTIN P TORNAI
• 金额: $ 58.77万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-19 至 2007-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6659816
• 关键词: bioimaging /biomedical imaging; biomedical equipment development; breast neoplasm /cancer diagnosis; clinical research; computed axial tomography; computer data analysis; digital imaging; female; human subject; image enhancement; single photon emission computed tomography

DESCRIPTION (provided by applicant)The overall goal of this proposal is to develop a hybrid, dual-modality x-ray computed tomography (XCT) and single photon emission computed tomography (SPECT) scanner for dedicated breast and axillary imaging, termed application specific emission and transmission tomography (ASETT). This noninvasive imaging tool is intended to provide volumetric, co-registered anatomical and functional imaging data for improved diagnosis of breast cancer. The XCT component of the system can provide structural three-dimensional images of the breast and axillary region with exposure near that of dual-view screening mammography, greatly improving the detectability of low contrast lesions in the breast, enhancing the spatially-dependent attenuation correction of the SPECT data, and facilitating better interpretation and quantification of the SPECT data by objectively guiding region of interest selection. This proposal represents the initial technology development for a dedicated breast ASETT system. A prototype, dedicated SPECT scanner has previously been investigated, and a gantry has been developed that facilitates a new class of hemispherical acquisition orbits about a pendant breast. This proposal will (1) extend the capabilities and performance characteristics of the SPECT camera and gantry, (2) develop and optimize the dedicated XCT scanner, and (3) integrate the two into a single system. The new SPECT system will have improved intrinsic spatial resolution (4.5mm) and intrinsic energy resolution (10% FWHM), and an expanded field-of-view, with fully computer controllable degrees of freedom. The XCT system will incorporate a novel x-ray source/filtration approach to mammographic imaging with a pseudo- monochromatic beam and a state-of-the-art, flat-panel, scintillator-based digital detector to reach <1mm isotropic reconstructed resolution. The ASETT detector system will be characterized and optimized for tomographic breast and axillary imaging. Novel orbits to sufficiently sample the pendant breast and axillary region will be developed, and trade-offs between sequential or simultaneous XCT/SPECT imaging, resolution, signal-to-noise, and radiation dose to the breast volume will be investigated. Appropriate phantoms will be used to quantitatively assess image quality and dose. Finally, the dual-modality ASETT system will be clinically evaluated with pilot patient studies.

描述（由申请人提供）本提案的总体目标是开发一种混合、双模态X射线计算机断层扫描（XCT）和单光子发射计算机断层扫描（SPECT）扫描仪，用于专用乳腺和腋窝成像，称为专用发射和透射断层扫描（ASETT）。这种非侵入性成像工具旨在提供体积、共配准的解剖和功能成像数据，以改善乳腺癌的诊断。该系统的XCT组件可以提供乳房和腋窝区域的结构三维图像，其曝光接近双视图筛查乳房X线摄影的曝光，大大提高了乳房中低对比度病变的可检测性，增强了SPECT数据的空间依赖性衰减校正，并通过客观地引导感兴趣区域选择来促进SPECT数据的更好解释和量化。该提案代表了专用乳腺ASETT系统的初步技术开发。一个原型，专用SPECT扫描仪以前已经调查，并已开发的机架，有利于一类新的半球形采集轨道下垂的乳房。该提案将（1）扩展SPECT摄像机和机架的功能和性能特征，（2）开发和优化专用XCT扫描仪，以及（3）将两者集成到单个系统中。新的SPECT系统将具有改进的固有空间分辨率（4.5 mm）和固有能量分辨率（10% FWHM），以及扩展的视场，具有完全计算机可控的自由度。XCT系统将采用新型X射线源/过滤方法进行乳房X线摄影成像，采用伪单色光束和最先进的平板、基于闪烁器的数字探测器，以达到<1 mm的各向同性重建分辨率。ASETT探测器系统将针对乳房和腋窝断层成像进行表征和优化。将开发新的轨道，以充分采样下垂的乳房和腋窝区域，并将研究顺序或同时XCT/SPECT成像，分辨率，信噪比和辐射剂量的乳房体积之间的权衡。将使用适当的体模定量评估图像质量和剂量。最后，双模态ASETT系统将通过试点患者研究进行临床评价。