Simultaneous Emission and Transmission Mammotomography

同时发射和透射乳腺断层扫描

基本信息

  • 批准号:
    7122872
  • 负责人:
  • 金额:
    $ 42.16万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2002
  • 资助国家:
    美国
  • 起止时间:
    2002-09-19 至 2008-08-31
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant)The overall goal of this proposal is to develop a hybrid, dual-modality x-ray computed tomography (XCT) and single photon emission computed tomography (SPECT) scanner for dedicated breast and axillary imaging, termed application specific emission and transmission tomography (ASETT). This noninvasive imaging tool is intended to provide volumetric, co-registered anatomical and functional imaging data for improved diagnosis of breast cancer. The XCT component of the system can provide structural three-dimensional images of the breast and axillary region with exposure near that of dual-view screening mammography, greatly improving the detectability of low contrast lesions in the breast, enhancing the spatially-dependent attenuation correction of the SPECT data, and facilitating better interpretation and quantification of the SPECT data by objectively guiding region of interest selection. This proposal represents the initial technology development for a dedicated breast ASETT system. A prototype, dedicated SPECT scanner has previously been investigated, and a gantry has been developed that facilitates a new class of hemispherical acquisition orbits about a pendant breast. This proposal will (1) extend the capabilities and performance characteristics of the SPECT camera and gantry, (2) develop and optimize the dedicated XCT scanner, and (3) integrate the two into a single system. The new SPECT system will have improved intrinsic spatial resolution (4.5mm) and intrinsic energy resolution (10% FWHM), and an expanded field-of-view, with fully computer controllable degrees of freedom. The XCT system will incorporate a novel x-ray source/filtration approach to mammographic imaging with a pseudo- monochromatic beam and a state-of-the-art, flat-panel, scintillator-based digital detector to reach <1mm isotropic reconstructed resolution. The ASETT detector system will be characterized and optimized for tomographic breast and axillary imaging. Novel orbits to sufficiently sample the pendant breast and axillary region will be developed, and trade-offs between sequential or simultaneous XCT/SPECT imaging, resolution, signal-to-noise, and radiation dose to the breast volume will be investigated. Appropriate phantoms will be used to quantitatively assess image quality and dose. Finally, the dual-modality ASETT system will be clinically evaluated with pilot patient studies.
描述(由申请人提供)该提案的总体目标是开发一种混合双模态 X 射线计算机断层扫描 (XCT) 和单光子发射计算机断层扫描 (SPECT) 扫描仪,用于专用乳房和腋窝成像,称为应用特定发射和透射断层扫描 (ASETT)。这种非侵入性成像工具旨在提供体积、共同配准的解剖和功能成像数据,以改进乳腺癌的诊断。该系统的XCT组件可以提供乳腺和腋窝区域的结构三维图像,其曝光量接近双视图筛查乳腺X线摄影,大大提高了乳腺低对比度病变的可检出性,增强了SPECT数据的空间依赖性衰减校正,通过客观指导感兴趣区域选择,有利于更好地解释和量化SPECT数据。该提案代表了专用乳房 ASETT 系统的初步技术开发。之前已经研究了专用 SPECT 扫描仪原型,并开发了一个龙门架,以促进围绕下垂乳房的新型半球形采集轨道。该提案将 (1) 扩展 SPECT 相机和龙门架的功能和性能特征,(2) 开发和优化专用 XCT 扫描仪,以及 (3) 将两者集成到一个系统中。新的 SPECT 系统将提高固有空间分辨率 (4.5mm) 和固有能量分辨率 (10% FWHM),并扩大视场,并具有完全计算机可控的自由度。 XCT 系统将采用一种新颖的 X 射线源/过滤方法来进行乳腺 X 线摄影成像,采用伪单色光束和最先进的平板闪烁体数字探测器,以达到 <1mm 的各向同性重建分辨率。 ASETT 探测器系统将针对乳房和腋窝断层成像进行表征和优化。将开发对下垂乳房和腋窝区域进行充分采样的新轨道,并将研究顺序或同时 XCT/SPECT 成像、分辨率、信噪比和乳房体积的辐射剂量之间的权衡。将使用适当的模型来定量评估图像质量和剂量。最后,双模态 ASETT 系统将通过试点患者研究进行临床评估。

项目成果

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MARTIN P TORNAI其他文献

MARTIN P TORNAI的其他文献

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{{ truncateString('MARTIN P TORNAI', 18)}}的其他基金

Simultaneous Emission and Transmission Mammotomography
同时发射和透射乳腺断层扫描
  • 批准号:
    6508899
  • 财政年份:
    2002
  • 资助金额:
    $ 42.16万
  • 项目类别:
Simultaneous Emission and Transmission Mammotomography
同时发射和透射乳腺断层扫描
  • 批准号:
    8034699
  • 财政年份:
    2002
  • 资助金额:
    $ 42.16万
  • 项目类别:
Simultaneous Emission and Transmission Mammotomography
同时发射和透射乳腺断层扫描
  • 批准号:
    8264320
  • 财政年份:
    2002
  • 资助金额:
    $ 42.16万
  • 项目类别:
Simultaneous Emission and Transmission Mammotomography
同时发射和透射乳腺断层扫描
  • 批准号:
    6941265
  • 财政年份:
    2002
  • 资助金额:
    $ 42.16万
  • 项目类别:
Simultaneous Emission and Transmission Mammotomography
同时发射和透射乳腺断层扫描
  • 批准号:
    6802353
  • 财政年份:
    2002
  • 资助金额:
    $ 42.16万
  • 项目类别:
Simultaneous Emission and Transmission Mammotomography
同时发射和透射乳腺断层扫描
  • 批准号:
    6659816
  • 财政年份:
    2002
  • 资助金额:
    $ 42.16万
  • 项目类别:
Workshop on the Nuclear Radiology of Breast Cancer
乳腺癌核放射学研讨会
  • 批准号:
    6606690
  • 财政年份:
    2002
  • 资助金额:
    $ 42.16万
  • 项目类别:
Simultaneous Emission and Transmission Mammotomography
同时发射和透射乳腺断层扫描
  • 批准号:
    7802906
  • 财政年份:
    2002
  • 资助金额:
    $ 42.16万
  • 项目类别:
Simultaneous Emission and Transmission Mammotomography
同时发射和透射乳腺断层扫描
  • 批准号:
    7654594
  • 财政年份:
    2002
  • 资助金额:
    $ 42.16万
  • 项目类别:
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