Ethnic differences in stress induced sodium regulation and blood pressure

应激引起的钠调节和血压的种族差异

• 批准号: 6642483
• 负责人: GREGORY ALAN HARSHFIELD
• 金额: $ 21.22万
• 依托单位: AUGUSTA UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-07-01 至 2007-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6642483
• 关键词: African American; adolescence (12-20); behavioral /social science research tag; blood pressure; blood volume; caucasian American; clinical research; dietary sodium; essential hypertension; genetic polymorphism; hemodynamics; human subject; nutrition related tag; racial /ethnic difference; renin angiotensin system; saluresis; social competition; stress; vasomotion

DESCRIPTION (provided by applicant) Essential hypertension has reached epidemic proportions in the African American (AA) community. Differences in the ability to regulate sodium adequately in a high salt environment and differences in stress have been hypothesized to contribute to the differences in essential hypertension between AAs and European Americans (Eas). The objective of Project 2 is to study the interactive relationship between salt and stress in the development of the ethnic differences in essential hypertension. The general hypothesis of this proposal is as follows: AAs compared to EAs are genetically predisposed to show slower natriuresis during and following stress due to differences in the regulation of vasoactive and volume regulatory agents. This results in extended periods of elevated blood pressure. The increased blood pressure load leads to the early development of preclinical disease states. Therefore, the first three aims of the study are to contrast AAs and EAs before, during, and two hours following a 60 minute behavioral challenge on changes in sodium handling (Aim 1), hemodynamic functioning (Aim 2), and vasoactive and volume regulatory agents of the sympathetic nervous system, the renin-angiotensin-aldosterone system, and the endothelial system (Aim 3). The fourth aim of the study is to relate the response patterns to preclinical disease states of the heart (left ventricular mass), kidneys (micro albumin), and vasculature (pulse wave velocity, endothelial dependent vasodilation). The fifth aim of the study is to determine if the response pattern observed during laboratory testing is associated with blood pressure functioning during ambulatory testing. The final aims of the study are to determine the genetic polymorphism(s) associated with the hemodynamic change in blood pressure following stress. The proposed study will contribute significantly to the understanding of how salt and stress interact in the development of hypertension in AAs.

描述（由申请人提供） 原发性高血压在非洲已达到流行病的程度， 美国（AA）社区调节钠的能力差异 在高盐环境和压力的差异， 假设有助于原发性高血压的差异 AAs和欧洲裔美国人（Eas）之间的关系。项目2的目标是 研究了盐胁迫在开发过程中的相互作用关系 高血压的种族差异。一般假设 该建议的主要内容如下：与EA相比，AA在基因上是 在压力期间和压力之后， 血管活性和容量调节剂调节的差异。 这会导致长时间的血压升高。增加的 血压负荷导致临床前疾病的早期发展 states.因此，本研究的前三个目的是对比AAs和 在60分钟行为挑战之前、期间和之后两小时的EA 钠处理（目标1）、血流动力学功能（目标2）和 交感神经系统的血管活性和容量调节剂， 肾素-血管紧张素-醛固酮系统和内皮系统（Aim 3）。的 研究的第四个目的是将反应模式与临床前 心脏（左心室质量），肾脏（微量白蛋白）， 和脉管系统（脉搏波速度、内皮依赖性血管舒张）。 研究的第五个目的是确定观察到的反应模式是否 在实验室测试期间与血压功能相关， 门诊检查这项研究的最终目的是确定基因 与血压血流动力学变化相关的多态性 压力之后。拟议的研究将大大有助于 了解盐和压力如何在发展中相互作用 AA中的高血压。