MECHANISM OF SICKLE CELL RETENTION IN THE RETINAL VASCULATURE

改编自申请者摘要)PiG.Lutty将调查影响 白介素1和肿瘤坏死因子α上调黏附分子 人镰状红细胞在视网膜微血管系统中的滞留 一种只保留SS4细胞(密集SS细胞)的大鼠模型 正常情况下。第二个假设将被调查，即 人α和β基因表达水平较高的转基因小鼠 珠蛋白基因具有更早的发病和更严重的视网膜病变 如果动物接受血管闭塞治疗，血管闭塞发生得更快 脂多糖，可能通过机制刺激黏附分子上调 与在大鼠模型中观察到的类似。

Adapted from Applicant's Abstract) PI G. Lutty will investigate the effect of the cytokines IL-1 and TNFalpha which up-regulate adhesion molecules on retention of human sickle erythrocytes in the retinal microvasculature in a rat model in which only SS4 cells (dense SS cells) are retained under normal conditions. A second hypothesis will be investigated that transgenic mice with higher levels of expression of human alpha and BetaS- globin genes have an earlier onset and more severe retinopathy and that the onset of vaso-occlusion occurs more rapidly if the animals receive LPS, which may stimulate up-regulation of adhesion molecules by mechanisms similar to those observed in the rat model.