Plasticity of Thalamic Inputs of Inhibitory Neurons

抑制性神经元丘脑输入的可塑性

• 批准号: 6740746
• 负责人: ZAIRA MATEO-MAYOL
• 金额: $ 4.41万
• 依托单位: PONCE SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-11-16 至 2008-05-15
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6740746
• 关键词: AMPA receptors; NMDA receptors; calcium channel; electrophysiology; glutamate receptor; laboratory mouse; learning; long term potentiation; microelectrodes; neural information processing; neural plasticity; neuroanatomy; neurons; neurotransmitter antagonist; organ culture; perception; predoctoral investigator; synapses; thalamus; voltage /patch clamp

DESCRIPTION (provided by applicant): Cortical sensory maps are important for perceptual learning. Cortical inhibition has an important role in the formation, maintenance and adaptability of these maps. We hypothesize that long-term potentiation (LTP) of thalamocortical synapses onto inhibitory neurons is important for the refinement of sensory maps. Specific Aim 1: The first aim of this study is to determine if LTP can be elicited at thalamocortical synapses onto inhibitory neurons. Specific Aim 2: The aim of this experiment is to determine if LTP is dependent on NMDA receptors, calcium-permeable AMPA receptors, metabotropic glutamate receptors or L-type voltage dependent calcium channels, using selective receptor antagonists. Specific Aim 3: The aim of this expedment is to determine if LTP of thalamic inputs onto inhibitory neurons is dependent on a critical period. The results of this project will increase our understanding of the mechanisms involve in perceptual learning.

描述（由申请人提供）：皮层感觉图对知觉学习很重要。皮层抑制在这些图谱的形成、维持和适应性中起着重要作用。我们假设丘脑皮质突触对抑制性神经元的长期增强（LTP）对感觉地图的细化很重要。具体目的1：本研究的第一个目的是确定LTP是否可以在丘脑皮质突触上被激发到抑制性神经元上。特异性目的2：本实验的目的是通过选择性受体拮抗剂确定LTP是否依赖于NMDA受体、钙通透性AMPA受体、代谢性谷氨酸受体或l型电压依赖性钙通道。具体目的3：本研究的目的是确定丘脑输入到抑制性神经元的LTP是否依赖于一个关键时期。这个项目的结果将增加我们对感知学习机制的理解。