Plasticity of Thalamic Inputs of Inhibitory Neurons
Plasticity of Thalamic Inputs of Inhibitory Neurons
批准号:
6740746
负责人:
ZAIRA MATEO-MAYOL
金额:
$4.41万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2003
资助国家:
美国
项目状态:
已结题
起止时间:
2003-11-16 至 2008-05-15
关键词:
AMPA receptors NMDA receptors calcium channel electrophysiology glutamate receptor laboratory mouse learning long term potentiation microelectrodes neural information processing neural plasticity neuroanatomy neurons neurotransmitter antagonist organ culture perception predoctoral investigator synapses thalamus voltage /patch clamp
中文摘要
描述(由申请人提供):皮层感觉图对知觉学习很重要。皮层抑制在这些图谱的形成、维持和适应性中起着重要作用。我们假设丘脑皮质突触对抑制性神经元的长期增强(LTP)对感觉地图的细化很重要。具体目的1:本研究的第一个目的是确定LTP是否可以在丘脑皮质突触上被激发到抑制性神经元上。特异性目的2:本实验的目的是通过选择性受体拮抗剂确定LTP是否依赖于NMDA受体、钙通透性AMPA受体、代谢性谷氨酸受体或l型电压依赖性钙通道。具体目的3:本研究的目的是确定丘脑输入到抑制性神经元的LTP是否依赖于一个关键时期。这个项目的结果将增加我们对感知学习机制的理解。
英文摘要
DESCRIPTION (provided by applicant): Cortical sensory maps are important for perceptual learning. Cortical inhibition has an important role in the formation, maintenance and adaptability of these maps. We hypothesize that long-term potentiation (LTP) of thalamocortical synapses onto inhibitory neurons is important for the refinement of sensory maps. Specific Aim 1: The first aim of this study is to determine if LTP can be elicited at thalamocortical synapses onto inhibitory neurons. Specific Aim 2: The aim of this experiment is to determine if LTP is dependent on NMDA receptors, calcium-permeable AMPA receptors, metabotropic glutamate receptors or L-type voltage dependent calcium channels, using selective receptor antagonists. Specific Aim 3: The aim of this expedment is to determine if LTP of thalamic inputs onto inhibitory neurons is dependent on a critical period. The results of this project will increase our understanding of the mechanisms involve in perceptual learning.
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Plasticity of Thalamic Inputs of Inhibitory Neurons
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批准号:7162508
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项目类别:
-
资助金额:$4.41万
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财政年份:2003
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负责人:ZAIRA MATEO-MAYOL
-
依托单位:
Plasticity of Thalamic Inputs of Inhibitory Neurons
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批准号:7316865
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项目类别:
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资助金额:$2.4万
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财政年份:2003
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负责人:ZAIRA MATEO-MAYOL
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依托单位:
Plasticity of Thalamic Inputs of Inhibitory Neurons
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批准号:6824084
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项目类别:
-
资助金额:$4.41万
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财政年份:2003
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负责人:ZAIRA MATEO-MAYOL
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依托单位:
Plasticity of Thalamic Inputs of Inhibitory Neurons
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批准号:6982810
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项目类别:
-
资助金额:$4.41万
-
财政年份:2003
-
负责人:ZAIRA MATEO-MAYOL
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依托单位:
海外基金