Plasticity of Thalamic Inputs of Inhibitory Neurons

抑制性神经元丘脑输入的可塑性

• 批准号: 7316865
• 负责人: ZAIRA MATEO-MAYOL
• 金额: $ 2.4万
• 依托单位: PONCE SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-11-16 至 2008-05-15
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7316865
• 关键词: 4-carboxyphenylglycine; Acids; Calcium; Calcium-Sensing Receptors; Cell Nucleus; Chromosome Pairing; D Aspartate; Dependence; Excitatory Amino Acid Antagonists; Frequencies; Glutamate Receptor; Hydroxyl Radical; L-Type Calcium Channels; Long-Term Potentiation; Maintenance; Maps; Metabotropic Glutamate Receptors; Mus; Nifedipine; Perceptual learning; Role; Sensory; Spermine; Synapses; Thalamic structure; aged; aspartate receptor; barrel cortex; critical developmental period; inhibitory neuron; receptor; research study

DESCRIPTION (provided by applicant): Cortical sensory maps are important for perceptual learning. Cortical inhibition has an important role in the formation, maintenance and adaptability of these maps. We hypothesize that long-term potentiation (LTP) of thalamocortical synapses onto inhibitory neurons is important for the refinement of sensory maps. Specific Aim 1: The first aim of this study is to determine if LTP can be elicited at thalamocortical synapses onto inhibitory neurons. Specific Aim 2: The aim of this experiment is to determine if LTP is dependent on NMDA receptors, calcium-permeable AMPA receptors, metabotropic glutamate receptors or L-type voltage dependent calcium channels, using selective receptor antagonists. Specific Aim 3: The aim of this expedment is to determine if LTP of thalamic inputs onto inhibitory neurons is dependent on a critical period. The results of this project will increase our understanding of the mechanisms involve in perceptual learning.

描述（由申请人提供）： 皮层感觉地图对知觉学习很重要。皮层抑制在这些地图的形成、维持和适应性中起着重要作用。我们假设，长时程增强（LTP）的丘脑皮层突触到抑制性神经元是重要的感觉地图的完善。具体目的1：本研究的第一个目的是确定是否可以在丘脑皮层突触上引起LTP到抑制性神经元。具体目标二：本实验的目的是使用选择性受体拮抗剂确定LTP是否依赖于NMDA受体、钙渗透性AMPA受体、代谢型谷氨酸受体或L型电压依赖性钙通道。具体目的3：本实验的目的是确定丘脑对抑制性神经元输入的LTP是否依赖于一个关键期。本研究的结果将增进我们对知觉学习机制的了解。