IMPROVING INSTITUTIONAL ANIMAL RESOURCES

描述(由申请人提供)： 这项设施改善申请将使UMB能够通过提供固定和可移动的设备来支持霍华德大厅六楼动物设施改造项目，从而继续发展校园整体动物护理和使用计划。该翻新项目将增加现有资源，以供研究人员使用，并提供因扩大大学管理学院的研究空间而需要的额外动物研究支持空间。具体地说，这项请求将提供额外的高密度笼子系统和相关的笼子更换罩，以满足对老鼠住房日益增长的需求，并为笼子清洗操作提供关键的基础设施设备，以及支持临床和诊断兽医病理学计划组成部分的固定设备。大约有350名由PHS资助和非PHS资助的首席调查员利用实验室动物。UMB是马里兰大学系统下的一个独立校园，获得了超过1亿美元的基于实验动物的研究项目。在1亿美元中，小灵通资助约9500万美元，余额约500万美元来自非小灵通来源。UMB的兽医资源将继续运营、开发和完善集中式动物资源计划。该计划为医学院、牙科、药房和退伍军人管理局进行的所有动物研究活动提供动物订购、饲养、管理和兽医护理。这些设施都获得了AAALAC的完全认证。这项申请的目的是实现确保人道照顾和使用实验动物的长期目标，为已资助和未决的PHS和非PHS项目提供最先进的笼养系统和基础设施关键设备，这些项目将占用翻新的Howard Hall六楼设施，符合PHS和美国农业部(USDA)的动物护理标准，提高运营的整体效率，并为UMB工作人员提供一个健康和安全的环境。为了实现这些目标，需要美国国立卫生研究院(NIH)的支持，以提供额外的高密度老鼠笼子系统、笼子更换和动物操作安全柜，为霍华德大厅六楼翻新项目提供关键和必要的洗手间支持设备，并提供必要的设备来支持兽医病理学计划。

DESCRIPTION (provided by applicant): This application for facilities improvement will enable the UMB to continue to develop the campus' overall animal care and use program by providing both fixed and moveable equipment in support of the Howard Hall sixth floor animal facilities renovation project. The renovation project will enhance the existing resources available to research faculty and provide additional animal research support space needed as a result of the expansion of research space at UMB. Specifically, this request will provide additional high density caging systems and related cage changing hoods to meet increasing demand for mouse housing and provide critical infrastructure equipment for the cage washing operation and fixed equipment supporting the Clinical and Diagnostic Veterinary Pathology program component. There are approximately 350 PHS- and non-PHS-funded Principal Investigators (PIs) utilizing laboratory animals. UMB is a separate campus under the University System of Maryland and receives in excess of $100 million in laboratory animal based research projects. Of the $100 million, PHS funds approximately $95 million with the balance of approximately $5 million derived from non-PHS sources. Veterinary Resources at UMB is continuing to operate, develop, and refine centralized animal resources program. This program provides for animal ordering, husbandry, management, and veterinary care for all animal research activities conducted in the Schools of Medicine, Dentistry, Pharmacy, and Veteran's Administration. These facilities are all fully AAALAC accredited. The aims of this application are to meet long-term goals of ensuring the humane care and use of laboratory animals, provide state of the art caging systems and infrastructure critical equipment for funded and pending PHS and non-PHS projects that will occupy the renovated Howard Hall sixth floor facility, comply with both PHS and United States Department of Agriculture (USDA) standards of animal care, to improve the overall efficiency of the operation, and to provide a healthy and safe environment for UMB staff. To accomplish these goals, National Institutes of Health (NIH) support is requested to provide additional high density mouse caging systems and cage changing and animal manipulation safety cabinets, to provide the critical and essential wash room support equipment for the Howard Hall sixth floor renovations project and to provide essential equipment to support the veterinary pathology program.