Osteoporosis in Hypercalciuric Kidney Stone Formers

高钙尿症肾结石形成者的骨质疏松症

• 批准号: 6622487
• 负责人: JOHN R ASPLIN
• 金额: $ 35.72万
• 依托单位: LITHOLINK CORPORATION
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-05-01 至 2005-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6622487
• 关键词: artificial intelligence; bone density; clinical research; computer program /software; computer system design /evaluation; disease /disorder proneness /risk; human population study; human subject; hypercalciuria; mathematical model; nephrocalcinosis; nephrolithiasis; osteoporosis; photon absorptiometry

The aim of our research is to determine the risk of bone disease in hypercalciuric kidney stone formers and their families by establishing an algorithm that takes into account bone mineral density (BMD), demographic characteristics diet history, and urine and serum chemistries, including markers of bone turnover. The algorithm will allow us to determine which hypercalciurics need clinical evaluation for osteoporosis and will form the basis of a disease management product. In the process of creating this algorithm, we will be the first to determine the prevalence of bone disease in hypercalciuric stone formers and their families and over time make some estimates of incidence rates. A longer- term goal of our research is to study the genetic underpinnings of osteoporosis and nephrolithasis in these families. PROPOSED COMMERCIAL APPLICATIONS: Litholink provides disease management services for kidney stone patients. We hope to use the algorithm developed in this research to expand out services to include bone disease management in kidney stone forming patients and their families.

我们研究的目的是通过建立一种考虑骨密度（BMD）、人口统计学特征、饮食史、尿液和血清化学成分（包括骨转换标志物）的算法，来确定高钙血症肾结石患者及其家庭发生骨病的风险。该算法将允许我们确定哪些高钙症患者需要骨质疏松症的临床评估，并将形成疾病管理产品的基础。在创建这个算法的过程中，我们将首先确定高钙尿酸结石患者及其家庭中骨病的患病率，并随着时间的推移对发病率进行一些估计。我们研究的长期目标是研究这些家族中骨质疏松症和肾结石的遗传基础。建议商业应用：Litholink为肾结石患者提供疾病管理服务。我们希望利用在这项研究中开发的算法来扩大服务范围，包括肾结石形成患者及其家属的骨病管理。

项目成果

Chitosan does not reduce post-prandial urinary oxalate excretion.

壳聚糖不会减少餐后尿草酸盐的排泄。

• DOI: 10.1007/s00240-006-0048-2
• 发表时间: 2006
• 期刊: Urological research
• 作者: Wolf,Joshua;Asplin,JohnR;Goldfarb,DavidS
• 通讯作者: Goldfarb,DavidS