Hand-held confocal line-scanner for intrasurgical use

描述(由申请人提供)： 提出了一种用于影像引导显微外科应用的实时手持共焦线扫描仪的实验室原型设计、产品开发和临床测试。行扫描提供手术内成像所需的分辨率、对比度和视野。在第一阶段的可行性项目中，实验室原型成功地展示了5-10微米分辨率的活体人体表皮细胞核和细胞细节的成像。在第二阶段，目标是定量表征活体人体皮肤的光学性能，将原型封装到手持共焦扫描仪产品中，并测试扫描仪在Mohs手术期间对患者基底细胞癌的成像。与目前基于冷冻病理的方法相比，实时原位共聚焦成像可以为莫氏外科医生和患者节省数小时的手术室时间。手持线扫描共聚焦显微镜将拥有外科医生和患者想要的一切：简单而坚固的设计，廉价(10K-2万美元)，用户友好的包装，控制和界面，以及标准的检测和显示系统。第一个应用是皮肤癌，但其他组织随后也将进行成像。目标用户是外科医生，对患者的潜在好处是：无痛、快速、成本较低，因此显著改善了医疗保健。

DESCRIPTION (provided by applicant): Design of a laboratory prototype, product development and clinical testing of a real-time hand-held confocal line-scanner is proposed for imaging-guided microsurgery applications. Line scanning offers resolution, contrast and field of view that are required for intrasurgical imaging. In the Phase I feasibility project, the laboratory prototype successfully demonstrated imaging of nuclear and cellular detail in human epidermis in vivo with 5-10 microns resolution. In Phase II, the goals are to quantitatively characterize optical performance within living human skin, package the prototype into a hand-held confocal scanner product, and test the scanner for imaging basal cell cancers on patients during Mohs surgery. Vis-a-vis the current method based on frozen pathology, real-time in situ confocal imaging may save both Mohs surgeon and patient several hours in the operating room. The hand-held line-scanning confocal microscope will have everything that surgeons and patients want: simple and robust design, inexpensive ($10K-20K), user-friendly package, controls and interface, and standard detection and display systems. The first application is for skin cancer but other tissues will be subsequently imaged as well. The intended users are surgeons, and the potential benefits to the patient are: painless, fast, less expensive and therefore significantly improved healthcare.