Hand-held confocal line-scanner for intrasurgical use

用于外科手术的手持式共焦线扫描仪

• 批准号: 6910652
• 负责人: JAY M EASTMAN
• 金额: $ 78.69万
• 依托单位: LUCID, INC.
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-14 至 2007-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6910652
• 关键词: basal cell carcinoma; bioengineering /biomedical engineering; bioimaging /biomedical imaging; biomedical equipment development; clinical biomedical equipment; clinical research; confocal scanning microscopy; diagnosis design /evaluation; histochemistry /cytochemistry; histopathology; human tissue; imaging /visualization /scanning; microsurgery; neoplasm /cancer diagnosis; noninvasive diagnosis; portable biomedical equipment; skin neoplasms; surgery material /equipment

DESCRIPTION (provided by applicant): Design of a laboratory prototype, product development and clinical testing of a real-time hand-held confocal line-scanner is proposed for imaging-guided microsurgery applications. Line scanning offers resolution, contrast and field of view that are required for intrasurgical imaging. In the Phase I feasibility project, the laboratory prototype successfully demonstrated imaging of nuclear and cellular detail in human epidermis in vivo with 5-10 microns resolution. In Phase II, the goals are to quantitatively characterize optical performance within living human skin, package the prototype into a hand-held confocal scanner product, and test the scanner for imaging basal cell cancers on patients during Mohs surgery. Vis-a-vis the current method based on frozen pathology, real-time in situ confocal imaging may save both Mohs surgeon and patient several hours in the operating room. The hand-held line-scanning confocal microscope will have everything that surgeons and patients want: simple and robust design, inexpensive ($10K-20K), user-friendly package, controls and interface, and standard detection and display systems. The first application is for skin cancer but other tissues will be subsequently imaged as well. The intended users are surgeons, and the potential benefits to the patient are: painless, fast, less expensive and therefore significantly improved healthcare.

描述（由申请人提供）： 设计一个实验室原型，产品开发和临床测试的实时手持共焦线扫描仪提出了成像引导显微外科应用。线扫描提供了外科手术内成像所需的分辨率、对比度和视野。在第一阶段的可行性项目中，实验室原型成功地展示了5-10微米分辨率的人体表皮细胞核和细胞细节成像。在第二阶段，目标是定量表征活体人类皮肤内的光学性能，将原型包装成手持式共焦扫描仪产品，并测试扫描仪在莫氏手术期间对基底细胞癌患者进行成像。与目前基于冷冻病理学的方法相比，实时原位共聚焦成像可以节省莫氏外科医生和患者在手术室中的几个小时。手持式线扫描共聚焦显微镜将拥有外科医生和患者想要的一切：简单而坚固的设计，廉价（1万-2万美元），用户友好的包装，控制和界面，以及标准的检测和显示系统。第一个应用是皮肤癌，但其他组织也将随后成像。预期用户是外科医生，对患者的潜在受益是：无痛、快速、便宜，因此显著改善了医疗保健。