CONNECTING PSYCHOSOCIAL FACTORS TO BIOLOGICAL MECHANISMS

将社会心理因素与生物机制联系起来

• 批准号: 6585835
• 负责人: BURTON H. SINGER
• 金额: $ 40.22万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-01-01 至 2008-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6585835
• 关键词: African American; age difference; autonomic nervous system; behavioral /social science research tag; biomarker; cardiovascular system; caucasian American; clinical research; cortisol; epidemiology; gender difference; human middle age (35-64); human old age (65+); human subject; hypothalamic pituitary adrenal axis; immune system; interpersonal relations; longitudinal human study; metabolism; personality; psychological aspect of aging; psychological stressor; psychophysiology; racial /ethnic difference; social psychology; socioeconomics

The purpose of this project is to identify biomarkers that are individually,and in combination, associated with diverse forms of life challenges and psychologicaland social factors characterizing persons from young adulthood into old age. Cumulative adversity with limited compensating advantages is hypothesized to be reflected in multiplebiological indicators of dysregulation. Conversely, the maintenance of high levels of wellbeing in the face of life's challenges is hypothesizedto be reflected in biological indicators of high levelsof functioning across multiple systems. Biomarker data collection will be carried out at 3 General Clinical Research Centers (at UCLA, University of Wisconsin, and Georgetown University) on a sub-sample of the MIDUS population (N=1350) and on a sub-sample of the Milwaukee African-American sample (N=200). The biomarkers reflect functioning of the hypothalamic-pituitary-adrenalaxis, the autonomic nervous system, the immunesystem, cardiovascular system, and metabolic processes. In addition to average/resting levels of such biomarkers, a laboratory cognitive and orthostatic challenge study is accompanied by assessments of salivary cortisol over time, heart-rate variability, and blood pressure dynamics. The quality of interpersonal relationships, the structuring of work experience and associated opportunities (or the lack thereof) for career advancement, a personal sense of purpose and personal growth, and the possession (or lack thereof) of effective strategies for management of diverse and often unanticipated life challenges are all phenomenathat have been associated with biological responses, usually focused on one, or at most two, measures at a time. We will assess associations between responses on multiple biomarkers individually, and in combination, with individual challenges and complex profiles reflecting cumulative challenges and a diversity of psychosocial factors and health characteristics. The integration of evidence about psychosocial and biological interrelationshipsfacilitates understanding of the factors associated with resilience and the maintenance of high levels of functioning. This, in turn, can provide a more rigorous foundation for multi-faceted health promotion programs in the future and facilitate understanding of the pronounceddeclines in disability amongthe elderly that have been occurring over the past two decades.

该项目的目的是确定与不同形式的生活挑战以及表征从青年期到老年的心理和社会因素相关的单独和组合的生物标志物。假设补偿优势有限的累积逆境反映在调节失调的多种生物学指标中。相反，假设在面对生活挑战时保持高水平的福祉可以反映在高水平的生物指标中。 跨多个系统运行。生物标志物数据收集将在 3 个综合临床研究中心（加州大学洛杉矶分校、威斯康星大学和乔治敦大学）针对 MIDUS 人群的子样本 (N=1350) 和密尔沃基非裔美国人样本的子样本 (N=200) 进行。生物标志物反映了下丘脑-垂体-肾上腺轴、自主神经系统、免疫系统、 心血管系统和代谢过程。除了此类生物标志物的平均/静息水平之外，实验室认知和体位挑战研究还伴随着对唾液皮质醇随时间、心率变异性和血压动态的评估。人际关系的质量、工作经验的结构和职业发展的相关机会（或缺乏）、个人的使命感和个人成长，以及拥有（或缺乏）管理各种且经常意想不到的生活挑战的有效策略，都是与生物反应相关的现象，通常一次集中于一种或最多两种措施。我们将单独评估多种生物标志物的反应之间的关联，并结合个体挑战和反映累积挑战以及多种心理社会因素和健康特征的复杂概况的综合评估。关于心理社会和生物相互关系的证据的整合有助于理解与复原力和维持高水平功能相关的因素。反过来，这可以为未来多方面的健康促进计划提供更坚实的基础，并有助于了解过去二十年来老年人残疾率的显着下降。