CONNECTING PSYCHOSOCIAL FACTORS TO BIOLOGICAL MECHANISMS

将社会心理因素与生物机制联系起来

• 批准号: 6585835
• 负责人: BURTON H. SINGER
• 金额: $ 40.22万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-01-01 至 2008-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6585835
• 关键词: African American; age difference; autonomic nervous system; behavioral /social science research tag; biomarker; cardiovascular system; caucasian American; clinical research; cortisol; epidemiology; gender difference; human middle age (35-64); human old age (65+); human subject; hypothalamic pituitary adrenal axis; immune system; interpersonal relations; longitudinal human study; metabolism; personality; psychological aspect of aging; psychological stressor; psychophysiology; racial /ethnic difference; social psychology; socioeconomics

The purpose of this project is to identify biomarkers that are individually,and in combination, associated with diverse forms of life challenges and psychologicaland social factors characterizing persons from young adulthood into old age. Cumulative adversity with limited compensating advantages is hypothesized to be reflected in multiplebiological indicators of dysregulation. Conversely, the maintenance of high levels of wellbeing in the face of life's challenges is hypothesizedto be reflected in biological indicators of high levelsof functioning across multiple systems. Biomarker data collection will be carried out at 3 General Clinical Research Centers (at UCLA, University of Wisconsin, and Georgetown University) on a sub-sample of the MIDUS population (N=1350) and on a sub-sample of the Milwaukee African-American sample (N=200). The biomarkers reflect functioning of the hypothalamic-pituitary-adrenalaxis, the autonomic nervous system, the immunesystem, cardiovascular system, and metabolic processes. In addition to average/resting levels of such biomarkers, a laboratory cognitive and orthostatic challenge study is accompanied by assessments of salivary cortisol over time, heart-rate variability, and blood pressure dynamics. The quality of interpersonal relationships, the structuring of work experience and associated opportunities (or the lack thereof) for career advancement, a personal sense of purpose and personal growth, and the possession (or lack thereof) of effective strategies for management of diverse and often unanticipated life challenges are all phenomenathat have been associated with biological responses, usually focused on one, or at most two, measures at a time. We will assess associations between responses on multiple biomarkers individually, and in combination, with individual challenges and complex profiles reflecting cumulative challenges and a diversity of psychosocial factors and health characteristics. The integration of evidence about psychosocial and biological interrelationshipsfacilitates understanding of the factors associated with resilience and the maintenance of high levels of functioning. This, in turn, can provide a more rigorous foundation for multi-faceted health promotion programs in the future and facilitate understanding of the pronounceddeclines in disability amongthe elderly that have been occurring over the past two decades.

该项目的目的是确定与各种形式的生活形式挑战和心理和社会因素相关的生物标志物，这些生物标志物是从成年到老年人的人的心理和社会因素。假设有限的补偿优势的累积逆境反映在功能障碍的多生物学指标中。相反，面对生活挑战的高水平福祉的维持是可以反映在高水平的生物学指标中 跨多个系统运行。生物标志物数据收集将在3个普通临床研究中心（UCLA，威斯康星大学和乔治敦大学）在MIDUS人群的子样本（n = 1350）和密尔沃基非裔美国人样本的子样本上进行。生物标志物反映了下丘脑 - 垂体 - 肾上腺素的功能，自主神经系统，免疫系统， 心血管系统和代谢过程。除了这种生物标志物的平均水平/静息水平外，一项实验室的认知和体位挑战研究还伴随着对唾液皮质醇的评估，随着时间的流逝，心率变异性和血压动态。人际关系的质量，工作经验的结构和相关机会的结构（或缺乏职业发展），个人的目标和个人成长感以及拥有（或缺乏的）拥有有效管理多样化且经常出现意外生活挑战的有效策略（通常都是与一个人相关的，通常都与一个人相关联，或者均已介绍一次，或者是两次，或者是两次，或者是在两次衡量中。我们将分别评估对多个生物标志物的反应，并结合个人挑战和复杂的概况，以反映累积挑战以及心理社会因素和健康特征的多样性。关于心理社会和生物学相互关系的证据的整合表明了对弹性和维持高功能相关的因素的理解。反过来，这可以为将来的多方面健康促进计划提供更严格的基础，并促进对过去二十年来发生的老年人中对残疾的发音人数的理解。