CORE--ENDOCRINOLOGY

核心--内分泌学

• 批准号: 6642244
• 负责人: WILLIAM B. MALARKEY
• 金额: $ 13.78万
• 依托单位: OHIO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-01 至 2003-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6642244
• 关键词: adrenocorticotropic hormone; aging; biomedical facility; cortisol; dehydroepiandrosterone; endocrinology; hypothalamic pituitary adrenal axis; immune system; insulinlike growth factor; neuroendocrine system; psychological stressor; spinal cord injury; wound healing

In this program project grant the influence of stress on wound healing will be examined in several human and animal models. Various dependent variables will be examined including aging, immunity, psychological and psychosocial variables, as well as spinal cord injury. Stress influences each of these entities and the most probably mediator between stress and these variables is the neuroendocrine system. In each project, the hypothalamic-pituitary-adrenal (HPA) axis will be examined to determine its role in the stress-related inhibition of wound healing. Plasma cortisol and/or the biologically-active free steroid found in salivary cortisol, as well as ACTH and DHEA will represent hormones of the HPA system. In addition we plan to examine pituitary growth hormone and IGF-1 because of their well-documented immune enhancing properties (Berczi, 1994). Dr Malarkey's endocrine lab has expertise in running all of the assays outlined in this proposal. In stead of having to train multiple technicians in five different laboratories, it is our opinion that one full-time technician can produce increased efficiency as well as accuracy in performance of these assays. Hence, we believe the endocrine core would produce cost savings as well as enhance accuracy of the assays. The endocrine core will keep Dr. Malarkey, the endocrinologist closely involved with the endocrine affects of the four projects, each of which has an endocrine component.

在这个项目中，格兰特将在几个人和动物模型中检验压力对伤口愈合的影响。将检查各种相关变量，包括年龄、免疫力、心理和心理社会变量，以及脊髓损伤。压力会影响这些实体中的每一个，而压力和这些变量之间最有可能的中介是神经内分泌系统。在每个项目中，将检查下丘脑-垂体-肾上腺(HPA)轴，以确定其在应激相关的伤口愈合抑制中的作用。血浆皮质醇和/或唾液皮质醇中具有生物活性的游离类固醇，以及ACTH和DHEA将代表HPA系统的激素。此外，我们还计划检查垂体生长激素和胰岛素样生长因子-1，因为它们有很好的免疫增强特性(Berczi，1994)。马拉基博士的内分泌实验室在运行这项提案中概述的所有化验方面拥有专业知识。我们认为，一名全职技术人员可以提高这些分析的效率和准确性，而不是必须在五个不同的实验室培训多名技术人员。因此，我们相信内分泌核心将产生成本节约以及提高分析的准确性。内分泌核心将留住内分泌学家马拉基博士，他密切参与了这四个项目的内分泌影响，每个项目都有内分泌成分。