Cellular and Molecular Physiology of Organ Function

描述（由申请人提供）：本培训计划的目的是 教育学生在现代理念和技术的综合生物 功能，利用分子生物学和遗传学，生物化学，细胞生物学， 药理学、膜物理学、蛋白质结构和计算机建模， 阐明分子和细胞的活动如何产生复杂的 生物体中的过程和行为。目的是教育学生 在哲学和现代生理学技术中， 研究，并推出他们在教学和研究的职业生涯，他们 可以为基础生物科学本身和人类 健康学生寻求学士或硕士学位的科学， 坚实的数学和生物学背景，以及高等本科教育 在细胞生物学、生物化学或物理科学的至少一个领域中。的 完成该计划的平均时间为5年;学生获得博士学位。 耶鲁大学毕业。40名初级培训教师来自 耶鲁大学医学院内的一些部门，并隶属于 细胞与分子生理学 生理跟踪或选定的其他部门。因为大多数 生物系统中的整合过程依赖于膜功能， 培训教师专注于细胞和膜研究，包括i） 上皮功能; ii）膜转运机制; iii）神经科学 包括可兴奋膜; iv）蛋白质合成和细胞内 运输;和v）蛋白质结构-功能。其他三个小组正在努力 vi）调节和第二信使功能，vii）肌肉和分子 运动，和八）心血管，代谢和运动生理学在大多数国家， 这些小组的技术专长涵盖器官生理学，膜生物物理学， 生物化学、分子生物学和遗传学，以及蛋白质结构。在 除了培训教师和他们的实验室，设施 提供给学员包括200多名教师在 生物与生物医学科学跨部门联合计划 (BBS)在耶鲁大学，以及一个海外范围的现代化的核心设施。

DESCRIPTION (provided by applicant): The purpose of this Training Program is to educate students in the modern ideas and techniques of integrated biological function, using molecular biology and genetics, biochemistry, cell biology, pharmacology, membrane physics, protein structure, and computer modeling to elucidate how the activities of molecules and cells give rise to complex processes and behaviors in living organisms. The aim is to educate students broadly in both the philosophy and the technologies of modern physiological research, and to launch them into careers in teaching and research where they can contribute significantly to basic biological science per se and to human health. Students are sought with a bachelor's or master's degree in science, a firm background in mathematics and biology, and advanced undergraduate training in a least one area of cell biology, biochemistry, or physical science. The average time for completing the program is 5 years; students receive the Ph.D. degree from Yale University. The forty primary training faculty are drawn from a number of departments within Yale School of Medicine and are affiliated with Cellular & Molecular Physiology, the combined Cell Biology and Molecular Physiology Track or selected other departments. Because the majority of integrative processes in biological systems depend upon membrane function, the training faculty are focused in cellular and membrane research including i) Epithelial function; ii) Mechanisms of membrane transport; iii) Neuroscience including excitable membranes; iv) Protein synthesis and intracellular transport; and v) Protein structure-function. Three other groups are working in vi) Regulation and second messenger functions, vii) Muscle and molecular motors, and viii) Cardiovascular, metabolic, and exercise physiology In most of these groups, technical expertise spans organ physiology, membrane biophysics, biochemistry, and molecular biology and genetics, and protein structure. In addition to the training faculty and their laboratories, the facilities available to trainees include the more than 200 faculty in the interdepartmental Combined Program in the Biological and Biomedical Sciences (BBS) at Yale, as well as a abroad range of modern core facilities.