Core--Animal

核心--动物

• 批准号: 6612405
• 负责人: W Dalton Dietrich
• 金额: $ 5.36万
• 依托单位: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-07-01 至 2003-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6612405
• 关键词: behavior test; biomedical facility; laboratory rat; magnetic resonance imaging; neurosurgery; spinal cord imaging /visualization; spinal cord injury

The purpose of the Animal Core is primarily to assist investigators in animal surgery, electrophysiology, behavioral testing, and imaging. This Core facility consists of personnel and equipment needed to perform procedures described in Projects 1-4. The Animal Core will conduct general animal preparation, including anesthesia, tracheotomy, catheterizations, temperature monitoring and regulation of physiological variables. The Core will assist investigators in preparing the animal models of spinal cord injury described in the individual projects. In addition, expertise is available to modify experimental animal preparations that may be required for future investigations. Personnel will also assist in the behavioral testing of the animal preparations that may be required for future investigations. Personnel will also assist in the behavioral testing of the rats following spinal cord injury, as well as in electrophysiological assessment of specific white matter tracts. Finally, this Core will provide expertise in MRI for the visualization of spinal cord contusions within the human spinal cord project.

动物核心的目的主要是帮助研究者进行动物手术、电生理学、行为测试和成像。该核心设施包括执行项目1-4所述程序所需的人员和设备。动物中心将进行一般动物准备，包括麻醉、气管切开术、插管、体温监测和生理变量调节。核心将协助研究人员准备在个别项目中描述的脊髓损伤的动物模型。此外，专业知识可用于修改未来研究可能需要的实验动物制剂。工作人员还将协助对未来研究可能需要的动物制剂进行行为试验。工作人员还将协助对脊髓损伤后的大鼠进行行为测试，以及对特定白色物质束进行电生理评估。最后，该核心将提供MRI方面的专业知识，以便在人类脊髓项目中可视化脊髓挫伤。